1-[2-fluoro-6-(trifluoromethyl)benzyl]-5-iodo-6-methylpyrimidine-2,4(1H,3H)-dione

CAS No.：1150560-54-5

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1-[2-fluoro-6-(trifluoromethyl)benzyl]-5-iodo-6-methylpyrimidine-2,4(1H,3H)-dione Basic information

Physical Form

Product Name:	1-[2-fluoro-6-(trifluoromethyl)benzyl]-5-iodo-6-methylpyrimidine-2,4(1H,3H)-dione
Synonyms:	1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-5-iodo-6-methyl-2,4(1H,3H)-Pyrimidine dione;1-[2-fluoro-6-(trifluoromethyl)benzyl]-5-iodo-6-methylpyrimidine-2,4(1H,3H)-dione;elagolix intermediate 5;1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-5-iodo-6-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione;EOS-60322;1-[[2-Fluoro-6-(trifluoromethyl)phenyl]methyl]-5-iodo-6-methyl-2,4(1H,3H)-pyrimidinedione1-[[2-Fluoro-6-(trifluoromethyl)phenyl]methyl]-5-iodo-6-methyl-2,4(1H,3H)-pyrimidinedione;1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-5-iodo-6-methylpyrimidine-2,4-dione;1-[[2-Fluoro-6-(trifluoromethyl)phenyl]methyl]-5-iodo-6-methyl- 2-2,4(1H,3H)- pyrimidinedione
CAS:	1150560-54-5
MF:	C13H9F4IN2O2
MW:	428.12
EINECS:	687-893-6
Product Categories:
Mol File:	1150560-54-5.mol

1-[2-fluoro-6-(trifluoromethyl)benzyl]-5-iodo-6-methylpyrimidine-2,4(1H,3H)-dione Chemical Properties

Melting point	>190oC (dec.)
density	1.88±0.1 g/cm3(Predicted)
storage temp.	-20°C Freezer, Under inert atmosphere
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
pka	8.04±0.40(Predicted)
form	Solid
color	White to Off-White
LogP	2

Safety Information

MSDS Information

1-[2-fluoro-6-(trifluoromethyl)benzyl]-5-iodo-6-methylpyrimidine-2,4(1H,3H)-dione Usage And Synthesis

Physical Form	Solid
Uses	1-[2-fluoro-6-(trifluoromethyl)benzyl]-5-iodo-6-methylpyrimidine-2,4(1H,3H)-dione is a useful research chemical.
Uses	1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-5-iodo-6-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione is an intermediate in the synthesis of Elagolix, a gonadotropin-releasing hormone antagonist (GnRH) used in the treatment of endometriosis.

1-[2-fluoro-6-(trifluoromethyl)benzyl]-5-iodo-6-methylpyrimidine-2,4(1H,3H)-dione Preparation Products And Raw materials

Raw materials	Benzaldehyde, 2-fluoro-6-(trifluoromethyl)-, oxime-->3-Fluorobenzotrifluoride-->2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE-->Benzeneacetic acid, 4-fluoro-.alpha.-(1-methylethyl)-, (.alpha.S)--->2-FLUORO-6-(TRIFLUOROMETHYL)BENZYLAMINE
Preparation Products	5-(2-Fluoro-3-methoxyphenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-2,4(1H,3H)-pyrimidinedione

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