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| GLYX 13 Basic information |
| Product Name: | GLYX 13 | | Synonyms: | L-ThreoninaMide, L-threonyl-L-prolyl-L-prolyl-;GLYX-13 trifluoroacetate;L-Threonyl-L-prolyl-L-prolyl-L-threoninamide trifluoroacetate;GLYX 13;Thr-Pro-Pro-Thr-NH2 trifluoroacetate;TPPT-amide trifluoroacetate;Rapastinel;GIYX-13 | | CAS: | 117928-94-6 | | MF: | C18H31N5O6 | | MW: | 413.47 | | EINECS: | | Product Categories: | | Mol File: | 117928-94-6.mol |
| GLYX 13 Chemical Properties |
| Boiling point | 844.2±65.0 °C(Predicted) | | density | 1.370±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | pka | 12.26±0.45(Predicted) | | form | powder | | color | white to tan |
| GLYX 13 Usage And Synthesis |
| Uses | Rapastinel is a novel antidepressant drug approved as an adjunctive therapy for the treatment of treatment-resistant major depressive disorder. It is a centrally active, intravenously administered (non-orally active) amidated tetrapeptide (Thr-Pro-Pro-Thr-NH2) that acts as a selective, weak partial agonist (mixed antagonist/agonist) of an allosteric site at the glycine site of the NMDA receptor complex (Emax ≈ 25%).The drug is a rapid-acting and long-lasting antidepressant as well as robust cognitive enhancer by virtue of its ability to both inhibit and enhance NMDA receptor-mediated signal transduction. | | Uses | GLYX-13 is a long lasting and rapid acting antidepressant. Investigational drug for the treatment of depressive disoder. | | Uses | GLYX-13 trifluoroacetate has been used as an activator of NMDA (N-methyl-D-aspartate) receptor. | | Biochem/physiol Actions | GLYX-13 is a glycine-site functional partial agonist (GFPA) selective modulator of the NMDA receptor (NMDAR). It is a brain penetrable tetrapeptide which acts as a positive allosteric modulator of the NMDA receptor, acting via the glycine site. GLYX-13 has been found to be a cognitive enhancer in learning models and is currently in clinical trials as an antidepressant. |
| GLYX 13 Preparation Products And Raw materials |
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