5-CHLORO-2-NITROANISOLE
5-CHLORO-2-NITROANISOLE
  • CAS No.:6627-53-8
Other grades of this product :
5-CHLORO-2-NITROANISOLE Basic information
Product Name:5-CHLORO-2-NITROANISOLE
Synonyms:4-chloro-2-methoxy-1-nitro-benzen;5-CHLORO-2-NITROANISOLE;4-CHLORO-2-METHOXYNITROBENZENE;4-Chloro-2-methoxynitrobenzene 98%;4-chloro-2-methoxy-1-nitro-benzene;4-Chloro-3-methoxy-1-nitrobenzene;5-CHLORO-2-NITROANISOLE 97%;5-Chloro-2-nitroanisole,97%
CAS:6627-53-8
MF:C7H6ClNO3
MW:187.58
EINECS:229-594-1
Product Categories:Building Blocks;Chemical Synthesis;Anisole;Nitro Compounds;Nitrogen Compounds;Organic Building Blocks;blocks;NitroCompounds;Miscellaneous;Nitro Compounds;Nitrogen Compounds;Organic Building Blocks
Mol File:6627-53-8.mol
5-CHLORO-2-NITROANISOLE Chemical Properties
Melting point 70-72 °C(lit.)
Boiling point 289.1±20.0 °C(Predicted)
density 1.4219 (rough estimate)
refractive index 1.6000 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility Chloroform, Ethyl Acetate
form Solid
color Yellow
CAS DataBase Reference6627-53-8(CAS DataBase Reference)
EPA Substance Registry System5-Chloro-2-nitroanisole (6627-53-8)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-37/39-36
WGK Germany 3
HS Code 2909309090
MSDS Information
ProviderLanguage
SigmaAldrich English
5-CHLORO-2-NITROANISOLE Usage And Synthesis
Chemical PropertiesSLIGHTLY YELLOW TO GREEN CRYSTALLINE POWDER
Uses5-Chloro-2-nitroanisole is involved in the synthesis of orally bioavailable anaplastic lymphoma kinases (ALK) inhibitors as anticancer drugs. In addition it is used in the synthesis of kinesin spindle protein (KSP) inhibitors which are responsible for the spindle pole separation which occurs during mitosis in cancer cells.
Uses5-Chloro-2-nitroanisole is involved in the synthesis of orally bioavailable anaplastic lymphoma kinases (ALK) inhibitors as anticancer drugs (1). In addition, it is used in the synthesis of kinesin spindle protein (KSP) inhibitors which are responsible for the spindle pole separation which occurs during mitosis in cancer cells (2).
5-CHLORO-2-NITROANISOLE Preparation Products And Raw materials
Raw materialsSodium bisulfite-->Copper(II) sulfate-->2-Methoxy-4-nitroaniline-->2-CHLORO-5-NITROANISOLE
Preparation Products4-CHLORO-2-ANISIDINE HYDROCHLORIDE

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