Product

3-Ethoxy-4-Methoxy-alpha-[(Methylsulfonyl)Methyl]-benzeneMethanaMine

CAS No.：253168-94-4

Other grades of this product :

3-Ethoxy-4-Methoxy-alpha-[(Methylsulfonyl)Methyl]-benzeneMethanaMine Basic information

Product Name:	3-Ethoxy-4-Methoxy-alpha-[(Methylsulfonyl)Methyl]-benzeneMethanaMine
Synonyms:	Apremilast Impurity 42;3-Ethoxy-4-methoxy-α-[(methylsulfonyl)methyl]benzenemethanamine;1-(3-Ethoxy-4-methoxyphenyl)-2- (methylsulofonyl)ethan-1-amine;Apremilast int;1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-amine;1-(3-Ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethylamine;1.1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-amine;2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine
CAS:	253168-94-4
MF:	C12H19NO4S
MW:	273.35
EINECS:	807-312-3
Product Categories:	apremilast intermediates
Mol File:	253168-94-4.mol

3-Ethoxy-4-Methoxy-alpha-[(Methylsulfonyl)Methyl]-benzeneMethanaMine Chemical Properties

Melting point	120 °C
Boiling point	469.6±45.0 °C(Predicted)
density	1.195±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly, Heated), Methanol (Sli
form	Solid
pka	6.84±0.10(Predicted)
color	White to Off-White

Safety Information

MSDS Information

3-Ethoxy-4-Methoxy-alpha-[(Methylsulfonyl)Methyl]-benzeneMethanaMine Usage And Synthesis

Uses	1-(3-Ethoxy-4-methoxy-phenyl)-2-methanesulfonylethylamine is used in the enantioselective synthesis of Apremilast (A729700) aminosulfone using catalytic asymetric hydrogenation. Apremilast EP Impurity H

3-Ethoxy-4-Methoxy-alpha-[(Methylsulfonyl)Methyl]-benzeneMethanaMine Preparation Products And Raw materials

Raw materials	3-Ethoxy-4-methoxy benzonitrile-->3-Ethoxy-4-methoxybenzaldehyde-->4-BROMO-2-ETHOXY-1-METHOXYBENZENE-->1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl) ethanone-->METHYLSULFONYLACETONITRILE-->METHANESULFONYLACETIC ACID-->1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethenamine-->Dimethyl sulfone
Preparation Products	(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethanaMine-->(R)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine

Welcome！

Please leave a message for us or use the following ways to contact us, we will reply to you as soon as possible, and provide you with the most sincere service, thank you.

NO. 18 ,Wujiang Road, Wulidian Street, Jiangbei District, Chongqing
+86-23-6139-8061 +86-13650506873
danny@chemdad.com sales@chemdad.com
www.chemdad.com
WhatsApp +86-13650506873