3-(Dimethylamino)-1-(pyridine-2-yl)prop-2-en-1-one

CAS No.：66521-54-8

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
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3-(Dimethylamino)-1-(pyridine-2-yl)prop-2-en-1-one Basic information

Synthesis

Product Name:	3-(Dimethylamino)-1-(pyridine-2-yl)prop-2-en-1-one
Synonyms:	3-(Dimethylamino)-1-(pyridin-2-yl)prop-2-en-1-one 98%;JR-8942, 3-(Dimethylamino)-1-(2-pyridyl)-2-propen-1-one, 97%;3-(DIMETHYLAMINO)-1-(2-PYRIDYL)-2-PROPE&;(E)-3-DiMethylaMino-1-(2-pyridyl)-2-propen-1-one, 98%;2-[3-(Dimethylamino)acryloyl]pyridine;3-(Dimethylamino)-1-(pyridin-2-yl)prop-2-en-1-one;(E)-3-dimethylamino-1-(2-pyridyl)prop-2-en-1-one;3-(Dimethylamino)-1-(2-pyridyl)-2-propen-1-one 95%
CAS:	66521-54-8
MF:	C10H12N2O
MW:	176.22
EINECS:
Product Categories:	C9 to C46;Heterocyclic Building Blocks;Pyridines
Mol File:	66521-54-8.mol

3-(Dimethylamino)-1-(pyridine-2-yl)prop-2-en-1-one Chemical Properties

Melting point	126-130 °C(lit.)
Boiling point	281.4±36.0 °C(Predicted)
density	1.07
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	6.25±0.70(Predicted)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
HS Code	2933399990

MSDS Information

3-(Dimethylamino)-1-(pyridine-2-yl)prop-2-en-1-one Usage And Synthesis

Synthesis	3-(Dimethylamino)-1-(pyridine-2-yl)prop-2-en-1-one was synthesised based on the literature. The reaction of (2g, 16.5mmol) of 2-acetylpyridine and DMF dimethyl acetal(7.84g) were suspended in 11ml of xylene and stir this reaction mixture for 16h at 110℃. Into the resulting mixture 10 ml of hexane added yellow colour precipitate was formed and allows stirring for 20min at 3℃. Resulting mixture was filtered and dried in vacuum to get a yellow colour powder.
Uses	3-(Dimethylamino)-1-(2-pyridyl)-2-propen-1-one may be used in the preparation of the 5-(heteroaryl)isoxazole derivatives, 5-(2-pyridyl)isoxazole and 3-methyl-5-(2-pyridyl)isoxazole. It may also be used to synthesize 7-(2-pyridyl)-1,2,4-triazolo[1,5-a]pyrimidine.
General Description	3-(Dimethylamino)-1-(2-pyridyl)-2-propen-1-one (1-(2′-Pyridyl)-3-dimethylamino-2-propen-1-one), an enaminone, is a hemilabile hybrid ligand. The preparation of cationic mononuclear rhodium(I) or iridium(I) complexes containing 3-(dimethylamino)-1-(2-pyridyl)-2-propen-1-one have been reported.

3-(Dimethylamino)-1-(pyridine-2-yl)prop-2-en-1-one Preparation Products And Raw materials

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