Other grades of this product :
| 7-HYDROXYFLAVONE Chemical Properties |
| Melting point | 245-247 °C (lit.) | | Boiling point | 320.83°C (rough estimate) | | density | 1.340±0.06 g/cm3 (20 ºC 760 Torr) | | refractive index | 1.5740 (estimate) | | Water Solubility | Insoluble in water | | form | powder to crystal | | pka | 7.02±0.40(Predicted) | | color | White to Light yellow | | BRN | 194089 | | CAS DataBase Reference | 6665-86-7(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39 | | WGK Germany | 3 | | Hazard Note | Irritant | | HS Code | 29329990 |
| 7-HYDROXYFLAVONE Usage And Synthesis |
| Synthesis | Acetylation of resorcinol acetic acid yields 2,4-dihydroxyacetophenone, which is then subjected to benzoylation and transposition to obtain (2-hydroxy-4-benzoyloxy)benzoylacetophenone. 7-hydroxyflavone was obtained by further cyclization reaction in a mixture of acetic acid and hydrochloric acid at 103° C for 7 h. | | Chemical Properties | off-white crystals | | Uses | antifungal, analgesic | | Uses | Reactant:- Acting as a biologically valuable acceptor in O-glycosidation reactions
- Involved in synthesis of fully phosphorylated flavones for use as pancreatic cholesterol esterase inhibitors
- For O-methylation with di-Me carbonate
- Linked by a polymethylene chain for synthesis of α1-adrenoceptor antagonists
- Involved in Baylis-Hillman reactions
- Involved in phase-transfer catalyzed glucosylation for synthesis of glucosylated flavonoids
| | Synthesis Reference(s) | Tetrahedron Letters, 31, p. 6497, 1990 DOI: 10.1016/S0040-4039(00)97100-4 | | Biological Activity | 7-Hydroxyflavone is a flavonoid isolated from M. indica with anti-inflammatory properties. It protects renal cells from nicotine (NIC)-induced cytotoxicity through the ERK/Nrf2/HO-1 pathway. |
| 7-HYDROXYFLAVONE Preparation Products And Raw materials |
|
日本语
한국어
Français
Deutsch
España
Türkiye