| Naphazoline nitrate Basic information |
| Product Name: | Naphazoline nitrate |
| Synonyms: | NAPHAZOLINE NITRATE;NAPHAZOLINE NITRATE SALT;NAPHAZOLINI NITRAS;LABOTEST-BB LT00134653;2-(1-NAPHTHYLMETHYL)IMIDAZOLINIUM NITRATE;2-(1-NAPHTHYLMETHYL)IMIDAZOLINE NITRATE;2-[1-NAPHTHYLMETHYL]IMIDAZOLINE NITRATE SALT;2-(1-NAPHTHYLMETHYL)-2-IMIDAZOLINE NITRATE |
| CAS: | 5144-52-5 |
| MF: | C14H15N3O3 |
| MW: | 273.29 |
| EINECS: | 225-915-4 |
| Product Categories: | API |
| Mol File: | 5144-52-5.mol |
| Naphazoline nitrate Chemical Properties |
| Melting point | 167-170 °C |
| solubility | Sparingly soluble in water, soluble in ethanol (96 per cent). |
| form | neat |
| Sensitive | Hygroscopic |
| BRN | 3779329 |
| InChIKey | ZAHXYMFVNNUHCP-UHFFFAOYSA-N |
| CAS DataBase Reference | 5144-52-5(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 22-36/37-60-36 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| RTECS | NJ4376000 |
| F | 3-10 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29332900 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| ALFA | English |
| Naphazoline nitrate Usage And Synthesis |
| Chemical Properties | White or almost white, crystalline powder. |
| Uses | antihistamine |
| Indications | Naphazoline hydrochloride and naphazoline nitrate are white or almost white crystalline powders soluble 1 in 6 and 1 in 36 water, respectively. These are potent sympathomimetic vasoconstrictors with a direct alpha-adrenergic receptor stimulatory action, and may be used as topical decongestants in 0.05% or 0.1% eyedrops. Frequent application of these solutions will produce a reactive hyperaemia. Instillation should not be repeated in less than 4-6 hours to avoid this rebound congestion. Naphazoline eyedrops cause slight mydriasis and are contra-indicated in patients with actual or suspected closed-angle glaucoma. Although not administered systemically, topical application of naphazoline has resulted in systemic absorption, and it is readily absorbed from the gastro-intestinal tract (Martindale, 1977). |
| Naphazoline nitrate Preparation Products And Raw materials |
| Raw materials | 1-Naphthaleneacetic acid |
| Preparation Products | Neomycin |
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