| POBN Basic information |
| Product Name: | POBN |
| Synonyms: | α-(4-Pyridyl N-oxide)-N-tert-butylnitrone,N-(4-Pyridylmethylene)-tert-butylamine N,N′-dioxide, N-tert-Butyl-α-(4-pyridyl)nitrone N′-oxide, POBN;alpha-(4-Pyridyl 1-oxide)-N-tert-butyl-nitrone, 99% 100MG;N-tert-Butyl-α-(4-pyridyl)nitrone Nμ-oxide;POBN, N-tert-Butyl-α-(4-pyridyl)nitrone Nμ-oxide, N-(4-Pyridylmethylene)-tert-butylamine N,Nμ-dioxide;2-Methyl-N-[(pyridine 1-oxide)-4-ylmethylene]-2-propanamine oxide;4-Pyridyl-1-oxide-tert-butyl Nitrone;N-[(Pyridine 1-oxide)-4-ylmethylene]-tert-butylamineN-oxide;N-[[(Pyridine-1-oxide)-4-yl]methylene]-1,1-dimethylethanamine-N-oxide |
| CAS: | 66893-81-0 |
| MF: | C10H14N2O2 |
| MW: | 194.23 |
| EINECS: | 266-512-3 |
| Product Categories: | Analytical Chemistry;ESR Spectrometry;Spin Trapping Reagents;Analytical Reagents;Analytical/Chromatography;Building Blocks;C10;Chemical Synthesis;Electron Spin Resonance (ESR/EPR) Spectroscopy;Heterocyclic Building Blocks;Pyridines;Spectroscopy |
| Mol File: | 66893-81-0.mol |
| POBN Chemical Properties |
| Melting point | 183-185 °C(lit.) |
| Boiling point | 330.68°C (rough estimate) |
| density | 1.1444 (rough estimate) |
| refractive index | 1.5000 (estimate) |
| storage temp. | room temp |
| solubility | water: soluble10mg/mL, clear, colorless to faintly yellow |
| form | White to off-white or colorless crystalline solid. |
| pka | 0.76±0.53(Predicted) |
| color | White to Light yellow |
| BRN | 1453764 |
| Safety Information |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| HS Code | 29333999 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| ACROS | English |
| POBN Usage And Synthesis |
| Chemical Properties | white to pale yellow crystalline powder |
| Uses | Spin trap reagent used to measure ethanol oxidation to 1-hydroxyethyl radical (HER) which can bind to protein. Has also been used in studies of DNA methylation, iron-mediated polyunsaturated fatty acid peroxidation, and free-radical formation by Alzheimer β-amyloid peptide. The formation of hydroxyl radical in chondrocytes and cartilage has been detected using POBN. |
| Uses | POBN is a cell permeable hydrophilic spin trap for in vitro studies. It is a water soluble analog of PBN with low paramagnetic impurities and does not require any further purification. POBN has also also been used in studies of DNA methylation, iron-mediated polyunsaturated fatty acid peroxidation, and free-radical formation by Alzheimer β-amyloid peptide. |
| POBN Preparation Products And Raw materials |
| Preparation Products | 4-PYRIDINECARBOXALDEHYDE N-OXIDE |
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