Product

N-Methyl-N-(trimethylsilyl)acetamide

CAS No.：7449-74-3

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N-Methyl-N-(trimethylsilyl)acetamide Basic information

Product Name:	N-Methyl-N-(trimethylsilyl)acetamide
Synonyms:	N-Methyl-N-TMS-acetamide;Acetamide,N-methyl-N-(trimethylsilyl)-;1-(4-phenylmethoxyphenyl)-2-propanamine;N-Methyl-N-trimethylsilyl-acetamide(MSA);MSA~N-Trimethylsilyl-N-methylacetamide;N-Methyl-N-trimethylsilyacetamideMSA(N-Trimethylsilyl-N-methylacetamide);N-Methyl-N-trimethylsilylacetamine;N-Methyl-N-(trimethylsilyl)acetamide,98%
CAS:	7449-74-3
MF:	C6H15NOSi
MW:	145.27
EINECS:	231-217-0
Product Categories:	Analytical Chemistry;GC Derivatizing Reagents;Si (Classes of Silicon Compounds);Silylacetamides;Silylation (GC Derivatizing Reagents);Si-N Compounds;Trimethylsilylation (GC Derivatizing Reagents)
Mol File:	7449-74-3.mol

N-Methyl-N-(trimethylsilyl)acetamide Chemical Properties

Boiling point	159-161 °C(lit.)
density	0.904 g/mL at 20 °C(lit.)
refractive index	n20/D 1.439
Fp	48 °C
storage temp.	-20°C
form	lyophilized powder
pka	-0.11±0.70(Predicted)
color	Clear light yellow
Specific Gravity	0.906
Sensitive	Moisture Sensitive
BRN	506975
CAS DataBase Reference	7449-74-3(CAS DataBase Reference)
NIST Chemistry Reference	Acetamide, n-methyl-n-(trimethylsilyl)-(7449-74-3)
EPA Substance Registry System	Acetamide, N-methyl-N-(trimethylsilyl)- (7449-74-3)

Safety Information

Hazard Codes	Xi
Risk Statements	10-36/37/38
Safety Statements	37/39-16
RIDADR	UN 1993 3/PG 3
WGK Germany	3
F	10-21
TSCA	Yes
HazardClass	3
PackingGroup	III
HS Code	29319090

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English
ALFA	English

N-Methyl-N-(trimethylsilyl)acetamide Usage And Synthesis

Chemical Properties	clear light yellow liquid
Uses	N-Methyl-N-trimethylsilylacetamide may be used as a derivatizing reagent for the following:??????? Quantification of the carbohydrate intermediates in glycation systems using gas chromatography coupled to mass spectrometry technique.??????? Characterization of damaged products of thymine and cytosine formed by the exposure to UV light in a hydrogen peroxide solution using gas chromatography/mass spectrometry with scan mode and selected ion monitoring mode.
General Description	N-Methyl-N-trimethylsilylacetamide is a trialkyl-silyl reagent and a versatile derivatizing agent used in gas chromatography (GC).
Purification Methods	N-Methyl-N-trimethylsilylacetamide [7449-74-3] M 145.3, b 48 -49o/11mm, 8 4o/13mm, 105-107o/35mm (solid at room temperature), d 4 0.90, n D 1.4379. A likely impurity is Et3N.HCl which can be detected by its odour. If it is completely soluble in *C6H6, then redistil; otherwise dissolve it in this solvent, filter and evaporate first in a vacuum at 12mm, then fractionate; all operations should be carried out in a dry N2 atmosphere. [Klebe et al. J Am Chem Soc 88 3390 1966, Ried & Suarez-Rivero Chem Ber 96 1473 1963, Beilstein 4 IV 4011.]

N-Methyl-N-(trimethylsilyl)acetamide Preparation Products And Raw materials

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