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| 3-(2-Pyrrolidinyl)pyridine Basic information |
| 3-(2-Pyrrolidinyl)pyridine Chemical Properties |
| Melting point | 235-236 °C(Solv: ethanol (64-17-5)) | | Boiling point | 107-108°C 2mm | | density | 1,074 g/cm3 | | refractive index | 1.54 | | Fp | 101°C | | storage temp. | 2-8°C | | solubility | H2O: 50 mg/mL | | form | liquid | | pka | 9.09±0.10(Predicted) | | Specific Gravity | 1.074 | | color | yellow | | Water Solubility | Soluble in acetone, chloroform and water (50mg/ml). | | Merck | 14,6712 | | BRN | 81968 | | Stability: | Hygroscopic, Light Sensitive, Moisture Sensitive | | CAS DataBase Reference | 5746-86-1(CAS DataBase Reference) |
| 3-(2-Pyrrolidinyl)pyridine Usage And Synthesis |
| Description | (±)-Nornicotine is a metabolite of nicotine that acts as a neuronal nicotinic acetylcholine receptor (nAChR) agonist. The α6 and α7 subunit-containing neuronal nAChRs are particularly responsive to nornicotine with EC50 values of approximately 4 and 17 μM, respectively, when expressed in Xenopus oocytes. Nornicotine promotes cell migration and destabilizes cell-cell junctions in an endothelial cell line. It is generally thought to be free from abuse potential, but it has been self-administered by rats. It can be detected in urine. | | Chemical Properties | Colourless Oil | | Uses | A metabolite of Nicotine ((N412420). Can catalyze aqueous aldol reactions. | | Uses | 3-(2-Pyrrolidinyl)pyridine is a tobacco alkaloid and the major Nicotine (N412420) metabolite in brain. Nornicotine appears to activate different nAChR subtypes, has a better pharmacokinetic profile, and produces less toxicity than Nicotine. Nornicotine shows a significant analgesic activity. Nicotine USP Related Compound F (3-(pyrrolidine-2-yl)pyridine).
| | Uses | A metabolite of Nicotine. Can catalyze aqueous aldol reactions | | Synthesis Reference(s) | Tetrahedron Letters, 37, p. 1137, 1996 DOI: 10.1016/0040-4039(96)00002-0 | | Safety Profile | Poison by intraperitoneal route.When heated to decomposition it emits very toxic fumesof NOx and HCl. See also NORNICOTINE |
| 3-(2-Pyrrolidinyl)pyridine Preparation Products And Raw materials |
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