2-Chloro-3-(trifluoromethyl)pyridine

CAS No.：65753-47-1

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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2-Chloro-3-(trifluoromethyl)pyridine Basic information

Product Name:	2-Chloro-3-(trifluoromethyl)pyridine
Synonyms:	2-Chloro-alpha,alpha,alpha-trifluoro-3-picoline;2-Chloro-3-(trifluoromethyl)ptridine;2-Chloro-3-trifuoromethylpyridine;2-CHLORO-3-(TRIFLUOROMETHYL)PYRIDINE, 97;2-CHLORO-3-(TRIFLUOROMETHYL)PYRIDINE;2,3-ctf;BUTTPARK 45\10-29;PYRIDINE, 2-CHLORO-3-(TRIFLUOROMETHYL)-
CAS:	65753-47-1
MF:	C6H3ClF3N
MW:	181.54
EINECS:	424-520-6
Product Categories:	Fluorine series;Chloropyridines;Halopyridines;C6Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyridine;Pyridine series;Halides;Pyridines;Pyridines derivates;1
Mol File:	65753-47-1.mol

2-Chloro-3-(trifluoromethyl)pyridine Chemical Properties

Melting point	36-40 °C(lit.)
Boiling point	166-168°C
density	1.416±0.06 g/cm3(Predicted)
Fp	180 °F
solubility	soluble in Methanol
pka	-1.68±0.10(Predicted)
form	Crystals
color	Semi-transparent
BRN	4179716
InChIKey	RXATZPCCMYMPME-UHFFFAOYSA-N
CAS DataBase Reference	65753-47-1(CAS DataBase Reference)

Safety Information

Hazard Codes	F,T,Xi
Risk Statements	11-25-36/37/38-52/53-48/25-34-24/25
Safety Statements	16-22-36/37/39-45-61-26-23
RIDADR	UN 2926 4.1/PG 2
WGK Germany	3
Hazard Note	Irritant
HazardClass	6.1
PackingGroup	III
HS Code	29333990

MSDS Information

Provider	Language
SigmaAldrich	English
ALFA	English

2-Chloro-3-(trifluoromethyl)pyridine Usage And Synthesis

Chemical Properties	semi-transparent crystals
Uses	2-Chloro-3-(trifluoromethyl)pyridine may be used in the preparation of 5,5′-bis(trifluoromethyl)-2,2′-bipyridine, via modified Ullmann reaction.
General Description	2-Chloro-3-(trifluoromethyl)pyridine is a trifluoromethyl-substituted pyridine derivative.

2-Chloro-3-(trifluoromethyl)pyridine Preparation Products And Raw materials

Raw materials	2-Chloro-3-iodopyridine-->3-Bromo-2-chloropyridine-->3-(trifluoromethyl)pyridine 1-oxide-->(Trifluoromethyl)trimethylsilane
Preparation Products	1-[3-(TRIFLUOROMETHYL)PYRID-2-YL]PIPERAZINE-->3-Trifluoromethylpyridine-->Leniolisib-->5-IODO-3-(TRIFLUOROMETHYL)-2(1H)-PYRIDINONE-->2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE-->5-bromo-2-methoxy-3-(trifluoromethyl)pyridine-->3-(Trifluoromethyl)pyridine-2-carboxylic acid-->2,6-Dichloro-3-(trifluoromethyl)pyridine

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