Product

N-(tert-Butoxycarbonyl)-L-phenylalanine

CAS No.：13734-34-4

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N-(tert-Butoxycarbonyl)-L-phenylalanine Basic information

Product Name:	N-(tert-Butoxycarbonyl)-L-phenylalanine
Synonyms:	n-[(1,1-dimethylethoxy)carbonyl]-l-phenylalanin;L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-;N-(tert-Butoxycarbonyl)-L-phenylalanine ,98.5%;Boc-L-phenylalanine ,98%;(2S)-2-(tert-Butoxycarbonylamino)-3-phenylpropionic acid;(S)-2-(tert-Butoxycarbonylamino)-3-phenylpropanoic acid;N-(tert-Butyloxycarbonyl)-L-phenylalanine;N-(tert-butoxycarbonyl)-L-phenylalaninal
CAS:	13734-34-4
MF:	C14H19NO4
MW:	265.3
EINECS:	237-305-5
Product Categories:	Phenylalanine [Phe, F];Boc-Amino Acids and Derivative;Protected Amino Acids;AMINOACIDS DERIVATIVES;Amino Acids;Amino Acids (N-Protected);Biochemistry;Boc-Amino Acids;Boc-Amino acid series;Amino Acids & Derivatives;Aromatics;Inhibitors;1
Mol File:	13734-34-4.mol

N-(tert-Butoxycarbonyl)-L-phenylalanine Chemical Properties

Melting point	85-87 °C(lit.)
Boiling point	408.52°C (rough estimate)
density	1.1356 (rough estimate)
refractive index	24.5 ° (C=1, EtOH)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in methanol, dichloromethane, dimethylformamide and N-methyl-2-pyrrolidone.
form	Fine Crystalline Powder
pka	3.88±0.10(Predicted)
color	White
optical activity	[α]20/D +25±1°, c = 1% in ethanol
BRN	2219729
CAS DataBase Reference	13734-34-4(CAS DataBase Reference)
EPA Substance Registry System	L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]- (13734-34-4)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	36-22-36/37/38-20/21/22
Safety Statements	39-26-36-24/25
WGK Germany	3
TSCA	Yes
HS Code	29242990

MSDS Information

Provider	Language
N-(tert-Butoxycarbonyl)-L-phenylalanine	English
ACROS	English
SigmaAldrich	English
ALFA	English

N-(tert-Butoxycarbonyl)-L-phenylalanine Usage And Synthesis

Chemical Properties	N-(tert-Butoxycarbonyl)-L-phenylalanine is white fine crystalline powder
Uses	N-(tert-Butoxycarbonyl)-L-phenylalanine is used in enantioselective hydrolysis of amino acid esters. Acts as an inhibitor of gastric acid secretion.
Uses	N-Boc-L-phenylalanine is a derivative of Phenylalanine used in enantioselective hydrolysis of amino acid esters.
Preparation	Sodium hydroxide (4.4 g, 0.11 mol) was placed in a flask, and dissolved in water (110 mL). Phenylalanine (16.5 g, 0.1 mol) was added, the suspension was stirred until a solution was obtained, and then tert-butanol (75 mL) was added. Boc2O (22.3 g, 0.12 mol) was then added with stirring over a period of 1 h, keeping the mixture near 0 ℃. A white precipitate was produced, and at the end of the addition the pH had dropped to 7.5–8.5. The mixture was then carefully acidified by the slow, continuous addition of saturated citric acid to give the product N-tert-butoxycarbonyl-L-phenylalanine (21.5 g, 81%); mp 85℃; [a]21D = t25:5 (c = 1, ethanol).

N-(tert-Butoxycarbonyl)-L-phenylalanine Preparation Products And Raw materials

Raw materials	1,4-Dioxane-->L-Phenylalanine-->BOC-D-Phenylalanine-->BOC-DL-PHE-OH
Preparation Products	N-Boc-L-Phenylalaninol-->N-SUCCINYL-L-PHENYLALANINE P-NITROANILIDE-->(alphaS)-alpha-Aminobenzenebutanoyl-L-leucyl-L-phenylalanine methyl ester mono(trifluoroacetate)-->H-PHE-TRP-OH-->TMC-58B-->Boc-Phe-Phe-OH-->ANGIOTENSIN I, HUMAN-->DELTORPHIN-->(S)-3-(Boc-amino)-4-phenylbutyric acid-->ANGIOTENSIN II, HUMAN

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