Other grades of this product :
| Tacalcitol Basic information |
| Product Name: | Tacalcitol | | Synonyms: | (1α，3β-5Z，7E，24R)-9，10-Secoholesta-5，7，10(19)-triene-1，3，24-triol;lα，24-Dihydroxycholecalciferol;lα，24R-Dihy-droxyvitamin D3;[5Z,7E,24R,(+)]-9,10-Secocholesta-5,7,10(19)-triene-1α,3β,24-triol;1α,24(R)-Dihydroxyvitamin D3;1α,24R-Dihydroxyvitamin D3;(1a,3b,5Z,7E,24R)-9,10-Secocholesta-5,7,10(19)-triene-1,3,24-triol;C12919 | | CAS: | 57333-96-7 | | MF: | C27H44O3 | | MW: | 416.64 | | EINECS: | | Product Categories: | Vitamin D3 analogs | | Mol File: | 57333-96-7.mol |
| Tacalcitol Chemical Properties |
| Boiling point | 565.0±50.0 °C(Predicted) | | density | 1.06 | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | pka | 14.43±0.40(Predicted) | | CAS DataBase Reference | 57333-96-7(CAS DataBase Reference) |
| Tacalcitol Usage And Synthesis |
| Description | Tacalcitol, the second vitamin D analog developed as a topical antipsoriatic, was
introduced for keratosis, psoriasis, ichthyosis, pityriasis rubra pilaris and palmoplantar
pustulosis and keratoderma. It shows improvement in appearance of skin lesions for psoriasis
patients without significant side effects. In patients with psoriasis vulgaris, it effectively
inhibits keratinocyte growth. Some in vitro studies have shown that tacalcitol inhibits
interleukin-1-α-induced granulocyte macrophage colony-stimulating-factor mRNA expression
of the human dermal microvascular endothelial cells, which may be involved in mediation of
angioproliferation in skin inflammation. | | Originator |
Teijin
(Japan) | | Brand name | Bonalfa | | Safety Profile | A poison by ingestion, subcutaneous, and intravenous routes. When heated to decomposition it emits acrid smoke and irritating vapors, |
| Tacalcitol Preparation Products And Raw materials |
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