4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE

CAS No.：757251-39-1

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE Basic information

Product Name:	4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE
Synonyms:	4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE;2-Pyridinecarboxamide,4-(4-amino-3-fluorophenoxy)-N-methyl-;4-(4-Amino-3-fluorophenoxy)pyridine-2-carboxylic acid methylamine;4-(4-amino-3-fluorophenoxy);4-(4-amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamid;Regorafenib Impurity 35;4-(4-Amino-3-fluorophenoxy)pyridine-2-carboxylic acid methylamide;4-(4-Amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide
CAS:	757251-39-1
MF:	C13H12FN3O2
MW:	261.25
EINECS:	692-721-8
Product Categories:	Regorafenib
Mol File:	757251-39-1.mol

4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE Chemical Properties

Melting point	143 °C
Boiling point	459.8±45.0 °C(Predicted)
density	1.305
vapor pressure	0Pa at 20℃
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), DMSO (Sparingly), Methanol (Slightly)
form	Solid
pka	13.92±0.46(Predicted)
color	Orange to Dark Red to Brown
Water Solubility	190mg/L at 20℃
LogP	1.3 at 25℃

Safety Information

MSDS Information

4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE Usage And Synthesis

Uses	4-(4-Amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide is a compound used as a reagent to synthesize Regorafenib (R143000), a multikinase inhibitor that is used to treat patients with advanced colorectal cancer.

4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE Preparation Products And Raw materials

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