1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid

CAS No.：849217-48-7

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid Basic information

Product Name:	1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid
Synonyms:	1-(4-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID;Cyclopropanecarboxylic acid, 1-[[(4-fluorophenyl)aMino]carbonyl]-;1-{[(4-fluorophenyl)aMino]carbonyl}cyclopropanecarboxylic acid;InterMediate of Cabozantinib;FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID;((4-fluorophenyl)carbamoyl)cyclopropane carboxylic acid;1-(5-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID;1-(4-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID(849217-48-7)
CAS:	849217-48-7
MF:	C11H10FNO3
MW:	223.2
EINECS:	1592732-453-0
Product Categories:
Mol File:	849217-48-7.mol

1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid Chemical Properties

Melting point	173.0 to 177.0 °C
Boiling point	475.2±30.0 °C(Predicted)
density	1.521
storage temp.	Sealed in dry,Room Temperature
solubility	soluble in Methanol
pka	3.48±0.20(Predicted)
form	powder to crystal
color	White to Almost white

Safety Information

MSDS Information

1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid Usage And Synthesis

Chemical Properties	White powdery substance.
Uses	1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid is a useful research chemical that can be used as a cabozantinib intermediate.

1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid Preparation Products And Raw materials

Raw materials

1,1-Cyclopropanedicarbonyl dichloride (9CI)-->Cyclopropanecarboxylic acid, 1-(chlorocarbonyl)- (9CI)-->METHYL 1-[(4-FLUOROPHENYL)CARBAMOYL]CYCLOPROPANECARBOXYLATE-->ethyl 1-(4-fluorophenylcarbaMoyl)cyclopropanecarboxylate-->1-(ethoxycarbonyl)cyclopropanecarboxylic acid-->1,1-Cyclopropanedicarboxylic acid monomethyl ester-->1,1-Cyclopropanedicarboxylic acid dimethyl ester-->3-Fluoroaniline-->1,1-Cyclopropanedicarboxylic acid-->4-Fluoroaniline-->Diethyl 1,1-cyclopropanedicarboxylate

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