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| 2-Amino-4-bromo-3-fluorobenzoic acid Basic information |
| 2-Amino-4-bromo-3-fluorobenzoic acid Chemical Properties |
| Boiling point | 332.0±42.0 °C(Predicted) | | density | 1.877±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 4.37±0.10(Predicted) |
| 2-Amino-4-bromo-3-fluorobenzoic acid Usage And Synthesis |
| Uses | 2-Amino-4-Bromo-3-Fluorobenzoic Acid is used in preparation of Quinazoline compounds as KRAS modulators and antitumor agents. | | Synthesis | The synthesis of 2-Amino-4-bromo-3-fluorobenzoic acid is as follows:To a mixture of 6-bromo-7-fluoroindoline-2,3-dione (18.9 g, 77.5 mmol) in 2 N NaOH (350 mL) at 0 oC, H2O2 (30%, 40 mL) was added. The mixture was stirred at room temperature for 16 h. The mixture was quenched with Na2SO3, and the mixture was acidified with conc. HCl to adjust pH to 2. The precipitate was collected by filtration and dried to afford the desired product as a white solid (17 g, 94% yield). |
| 2-Amino-4-bromo-3-fluorobenzoic acid Preparation Products And Raw materials |
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