Other grades of this product :
| trans-Cyclooctene-maleimide Basic information |
| Product Name: | trans-Cyclooctene-maleimide | | Synonyms: | TCO-PEG3-maleimide;trans-Cyclooctene-maleimide;(4E)-TCO-PEG3-Maleimide;Trans-Cyclooctene-PEG3-Maleimide,TCO-PEG3-Maleimide;6,9,12-Trioxa-2,16-diazanonadecanoic acid, 19-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-17-oxo-, 4-cycloocten-1-yl ester | | CAS: | 1609659-01-9 | | MF: | C26H41N3O8 | | MW: | 523.62 | | EINECS: | | Product Categories: | | Mol File: | 1609659-01-9.mol |
| trans-Cyclooctene-maleimide Chemical Properties |
| trans-Cyclooctene-maleimide Usage And Synthesis |
| Biochem/physiol Actions | Maleimide (thiol reactive) functionalized trans-cyclooctene derivative for incorporation of the cyclooctene moiety into thiol containing compounds or biomolecules. Trans-cyclooctenes are useful in strain-promoted copper-free click chemistry cycloaddition reactions with 1; 2; 4; 5-tetrazines. This cyclooctene will react with tetrazine functionalized compounds or biomolecules without the need for a catalyst to result in a stable covalent linkage. The 4+2 inverse electron demand Diels-Alder cycloaddition between trans-cyclooctene and tetrazines is the fastest biologically compatible ligation technology reported and has had many applications in biological labeling and imaging. The PEG spacer allows for increased water solubility; less aggregation and an increased distance between the thiol to be modified and the reactive alkene. |
| trans-Cyclooctene-maleimide Preparation Products And Raw materials |
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