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| 2-Chloroquinoline Basic information |
| 2-Chloroquinoline Chemical Properties |
| Melting point | 34-37 °C (lit.) | | Boiling point | 266-267 °C (lit.) | | density | 1.23 g/mL at 25 °C (lit.) | | refractive index | 1.6342 (estimate) | | Fp | >230 °F | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | methanol: 0.1 g/mL, clear | | form | Crystalline Powder, Crystals and/or Chunks or Fused Mass | | pka | 0.41±0.40(Predicted) | | color | White to yellow | | Water Solubility | Insoluble | | BRN | 112561 | | InChIKey | OFUFXTHGZWIDDB-UHFFFAOYSA-N | | CAS DataBase Reference | 612-62-4(CAS DataBase Reference) | | NIST Chemistry Reference | Quinoline, 2-chloro-(612-62-4) | | EPA Substance Registry System | Quinoline, 2-chloro- (612-62-4) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-37/39 | | WGK Germany | 3 | | RTECS | VB2320000 | | F | 8 | | TSCA | Yes | | HS Code | 29334900 |
| 2-Chloroquinoline Usage And Synthesis |
| Chemical Properties | white to yellowish crystals, powder, chunks or | | Uses | 2-Chloroquinoline is an intermediate used in the synthesis of various compounds that exhibits antifungal properties. | | Uses | 2-Chloroquinoline is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff. It reacts with benzotriazole, followed by cyclization with loss of nitrogen, gives the indolo[2,3-b]quinoline ring system for use in novel cytotoxic DNA topoisomerase II inhibitors. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 67, p. 7884, 2002 DOI: 10.1021/jo016196iSynthesis, p. 1013, 1987 DOI: 10.1055/s-1987-28152 | | Purification Methods | Purify it by crystallisation of its picrate to constant melting point (123-124o) from *benzene, regenerating the base and distilling it under vacuum [Cumper et al. J Chem Soc 1183 1962]. 2-Chloroquinoline can be crystallised from EtOH. Its picrate has m 123-124o (from EtOH). [Beilstein 20 H 359, 20/7 V 312.] |
| 2-Chloroquinoline Preparation Products And Raw materials |
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