3-(Trifluoromethyl)pyridine-2-carboxylic acid

CAS No.：87407-12-3

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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3-(Trifluoromethyl)pyridine-2-carboxylic acid Basic information

Product Name:	3-(Trifluoromethyl)pyridine-2-carboxylic acid
Synonyms:	3-(TRIFLUOROMETHYL)PYRIDINE-2-CARBOXYLIC ACID;3-(TRIFLUOROMETHYL)PICOLINIC ACID;3-(TRIFLUOROMETHYL)-2-PICOLINIC ACID;3-(trifluoromethyl)-2-pyridinecarboxylic acid;3-(Trifluoromethy)pyridine-2-carboxylic acid;3-(Trifluoromethyl)-2-pyridinecarboxylicacid(en);3-(Trifluoromethyl)picolinic acid, 2-Carboxy-3-(trifluoromethyl)pyridine;2-Pyridinecarboxylic acid, 3-(trifluoromethyl)-
CAS:	87407-12-3
MF:	C7H4F3NO2
MW:	191.11
EINECS:
Product Categories:	Carboxylic Acids;Pyridines;Acids and Derivatives;Heterocycles;Carboxylic Acids;Fluorine series;Aromatics;Intermediates
Mol File:	87407-12-3.mol

3-(Trifluoromethyl)pyridine-2-carboxylic acid Chemical Properties

Melting point	125-130°C
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
color	Off-White

Safety Information

Hazard Codes	Xi,T
Risk Statements	25-36/37/38
Safety Statements	26-45
RIDADR	2811
WGK Germany	3
HazardClass	IRRITANT
PackingGroup	Ⅲ
HS Code	2933399990

MSDS Information

3-(Trifluoromethyl)pyridine-2-carboxylic acid Usage And Synthesis

Uses	As Picolinic acid (P437220) derivative, 3-(Trifluoromethyl)pyridine-2-carboxylic acid can be used in the synthesis of oxazine derivatives that act as BACE inhibitors for treatment of diabetes and neurological disorders.
Uses	Picolinic acid (P437220) derivative used in the synthesis of oxazine derivatives that act as BACE inhibitors for treatment of diabetes and neurological disorders.
Synthesis Reference(s)	Tetrahedron, 50, p. 12259, 1994 DOI: 10.1016/S0040-4020(01)89575-2

3-(Trifluoromethyl)pyridine-2-carboxylic acid Preparation Products And Raw materials

Raw materials

2-Bromo-3-trifluoromethylpyridine-->2-Chloro-3-(trifluoromethyl)pyridine-->3-Trifluoromethylpyridine-->CARBON DIOXIDE

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