Product

1-NAPHTHOHYDROXAMIC ACID

CAS No.：6953-61-3

Other grades of this product :

1-NAPHTHOHYDROXAMIC ACID Basic information

Product Name:	1-NAPHTHOHYDROXAMIC ACID
Synonyms:	HDAC Inhibitor XIX, Compound 2 - CAS 6953-61-3 - Calbiochem;Naphthalene-1-carbohydroximic acid;N-Hydroxy-1-naphthalenecarboxamide;a-Naphthohydroxamic acid;NSC 57457;HDAC Inhibitor XIX, Compound 2;N-HYDROXYNAPHTHALENE-1-CARBOXAMIDE;alpha-naphthohydroxamicacid
CAS:	6953-61-3
MF:	C11H9NO2
MW:	187.19
EINECS:
Product Categories:	Hydroxylamines;Hydroxylamines (N-Substituted)
Mol File:	6953-61-3.mol

1-NAPHTHOHYDROXAMIC ACID Chemical Properties

storage temp.	2-8°C
solubility	DMSO: ≥5mg/mL
form	White solid
color	white to tan

Safety Information

Risk Statements	52
WGK Germany	3
RTECS	QJ1894500
HS Code	2928009090

MSDS Information

1-NAPHTHOHYDROXAMIC ACID Usage And Synthesis

Uses

1-Naphthohydroxamic Acid is a potent HDAC inhibitor with efficacy against HDAC8, HDAC1 and HDAC6.

Biochem/physiol Actions

1-Naphthohydroxamic Acid is a cell-permeable, potent, and selective histone deacetylase 8 (HDAC8) inhibitor. 1-Naphthohydroxamic acid selectively inhibits HDAC8 (IC50 = 14 μM) over class I HDAC1 and class II HDAC6 (IC50 >100 μM). Treatment of cells with 1-Naphthohydroxamic acid does not increase neither global histone H4 nor tubulin acetylation . Also in contrast to the pan-HDAC inhibitors the compound is not reducing total intracellular HDAC activity.

1-NAPHTHOHYDROXAMIC ACID Preparation Products And Raw materials

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