2-CHLORO-N-METHYLACETOACETAMIDE

CAS No.：4116-10-3

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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2-CHLORO-N-METHYLACETOACETAMIDE Basic information

Product Name:	2-CHLORO-N-METHYLACETOACETAMIDE
Synonyms:	alpha-chloroacetoaceticacidmonoethylamide;2-chloro-N-methyl-3-oxobutyramide;N-Methyl-2-chloroacetoacetamide;1-Chloroacetoacetomethylamine;A-ChloroAcetoN-Methylacetamide;α-chloro aceto N-methylacetamide;N-Methyl-2-chloro-3-oxobutanamide;2-chloro-3-keto-N-methyl-butyramide
CAS:	4116-10-3
MF:	C5H8ClNO2
MW:	149.58
EINECS:	223-907-5
Product Categories:
Mol File:	4116-10-3.mol

2-CHLORO-N-METHYLACETOACETAMIDE Chemical Properties

Melting point	78-80 °C
Boiling point	284.1±30.0 °C(Predicted)
density	1.2253 (rough estimate)
refractive index	1.5500 (estimate)
pka	10.01±0.46(Predicted)
EPA Substance Registry System	2-Chloro-N-methyl-3-oxobutanamide (4116-10-3)

Safety Information

Hazard Codes	T
Risk Statements	22-24-37/38-41-43
Safety Statements	26-28-36/37/39-45
RIDADR	2923
RTECS	AK3910000
HazardClass	8
PackingGroup	III

MSDS Information

2-CHLORO-N-METHYLACETOACETAMIDE Usage And Synthesis

Uses	2-Chloro-N-methyl-3-oxo-butanamide is used in the preparation of piperidinylmethyl (thiazolyl)phenylcarbamates which are useful as M3 muscarinic acetylcholine receptor antagonists for the treatment of chronic obstructive lung diseases, chronic bronchitis, asthma, and other disease.

2-CHLORO-N-METHYLACETOACETAMIDE Preparation Products And Raw materials

Raw materials

Methylamine-->Dichloroethane-->N-Methylacetoacetamide

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