2-Propylpiperidine

2-Propylpiperidine
  • CAS No.:3238-60-6

Important Notice

  1. This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
  2. This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
  3. The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.
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2-Propylpiperidine Basic information
Product Name:2-Propylpiperidine
Synonyms:2-PRIOPYLPIPERIDINE;2-PROPYLPIPERIDINE;2-N-PROPYLPIPERIDINE;(2R)-2-Propylpiperidine;(R)-2-Propylpiperidine;DL-CONIINE;CONIINE;CONIINE, DL-
CAS:3238-60-6
MF:C8H17N
MW:127.23
EINECS:221-801-3
Product Categories:Alkaloids
Mol File:3238-60-6.mol
2-Propylpiperidine Chemical Properties
Melting point -2℃
Boiling point 56-60 °C(Press: 13 Torr)
density 0.85 g/mL at 25 °C(lit.)
storage temp. Sealed in dry,2-8°C
form liquid
pkapK1:11.24(+1) (25°C,μ=0.5)
color , clear colorless to yellow-green
CAS DataBase Reference3238-60-6(CAS DataBase Reference)
Safety Information
Hazard Codes T
Risk Statements 23/24/25-40
Safety Statements 22-36/37/39-45
RIDADR UN 2810 6.1/PG 2
WGK Germany 3
HazardClass IRRITANT
HS Code 2933399990
ToxicityPiperidine alkaloid obtained from poison hemlock, Conium maculatum. Alkaline, steam volatile liquid (b.p. 167_x0003_C), mousy odor. Darkens and polymerizes in air. It can be reduced at high temperature with HI to n-octane and oxidized to pyridine-1-carboxylic acid. The hydrochloride is used as an antispasmodic.
MSDS Information
ProviderLanguage
SigmaAldrich English
2-Propylpiperidine Usage And Synthesis
Chemical PropertiesColorless liquid; darkens on exposure tolight and air; polymerizes; boils at 166°C(330.8°F); melts at -2°C (28.4°F); alkaline, pKa 3.1; density 0.845 at 20°C (68°F);slightly soluble in water and chloroform,readily soluble in most organic solvents.
UsesConiine is present in all parts of the plantpoison hemlock (Conium maculatum). It isthe first alkaloid to be synthesized and structure determined. Because of its high toxicity,its clinical application is very limited.
Synthesis Reference(s)Tetrahedron Letters, 26, p. 4633, 1985 DOI: 10.1016/S0040-4039(00)98771-9
Health HazardConiine is a highly toxic alkaloid. Thetoxic symptoms from ingestion are weakness,drowsiness, nausea, vomiting, muscle contraction, and labored breathing. A high dosecan cause convulsions, cyanosis, asphyxia,and death. Chronic ingestion of coniine produced adverse reproductive effects and spe cific developmental abnormalities in cattles.LD50 value, oral (mice): 100 mg/kg.
2-Propylpiperidine Preparation Products And Raw materials

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