4-TRIMETHYLSILYL-3-BUTYN-2-OL

CAS No.：6999-19-5

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

View the full Disclaimer

Other grades of this product :

4-TRIMETHYLSILYL-3-BUTYN-2-OL Basic information

Product Name:	4-TRIMETHYLSILYL-3-BUTYN-2-OL
Synonyms:	4-Trimethylsilyl-3-butynol, t;4-(triMethylsilyl)but-3-yn-2-ol;4-TRIMETHYLSILYL-3-BUTYN-2-OL, (+/-), 98%4-TRIMETHYLSILYL-3-BUTYN-2-OL, (+/-), 98%4-TRIMETHYLSILYL-3-BUTYN-2-OL, (+/-), 98%;TIMTEC-BB SBB009027;1-TRIMETHYLSILYLBUT-1-YNE-3-OL;(+/-) 4-TRIMETHYLSILYL-3-BUTYN-2-OL;4-TRIMETHYLSILYL-3-BUTYN-2-OL;4-TRIMETHYLSILYL-3-BUTYN-2-OL (+/-)
CAS:	6999-19-5
MF:	C7H14OSi
MW:	142.27
EINECS:
Product Categories:	Acetylenes;Acetylenic Alcohols & Their Derivatives;Ethynylsilanes;Si (Classes of Silicon Compounds);Si-(C)4 Compounds;Alkynes;Building Blocks;Chemical Synthesis;Internal;Organic Building Blocks
Mol File:	6999-19-5.mol

4-TRIMETHYLSILYL-3-BUTYN-2-OL Chemical Properties

Boiling point	76 °C
density	0.847 g/mL at 25 °C
refractive index	n 20/D 1.446
Fp	143 °F
storage temp.	2-8°C
solubility	highly soluble in all standard organic solvents (hexanes, toluene, CH2Cl2, EtOAc, alcohols, ethers). Partially soluble in water.
pka	13.78±0.20(Predicted)
form	clear liquid
color	Colorless to Light orange to Yellow
Specific Gravity	0.846
Hydrolytic Sensitivity	4: no reaction with water under neutral conditions
BRN	1923632
CAS DataBase Reference	6999-19-5(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26
RIDADR	1993
WGK Germany	3
TSCA	No
HazardClass	3
PackingGroup	III
HS Code	29319090

MSDS Information

Provider	Language
SigmaAldrich	English
ALFA	English

4-TRIMETHYLSILYL-3-BUTYN-2-OL Usage And Synthesis

Chemical Properties	Colorless liquid
Physical properties	bp 83–85°C (13 mmHg).
Uses	More recently, Mulzer has reported use of the corresponding allenylsilane derived from 4-TMS-3-butyn-2-ol for use in the synthesis of the C13–C18 fragment of branimycin (eq 2).
Preparation	racemic 4-trimethylsilyl-3-butyn-2-ol can be prepared by deprotonation with strong bases (BuLi, LDA, Grignards reagents) of trimethylsilylacetylene followed by addition to acetaldehyde.Deprotonation of 3-butyn-2- ol followed by quenching with excess trimethylsilyl chloride followed by concomitant hydrolysis of the trimethylsilyl ether is generally the most straightforward route.Enzymatic reduction of 4-TMS-3-butyn-2-one has also been used to prepare the reagent using alcohol dehydrogenase.Preparation of nonracemic 4-TMS-3-butyn-2-ol has been accomplished by asymmetric addition of dimethylzinc to acetaldehyde promoted by TADDOL or addition of a trimethylsilylvinylsulfoxide to acetaldehyde followed by thermal elimination of the sulfoxide.Asymmetric reduction of 4- TMS-3-butyn-2-one using stoichiometric reducing reagents, catalytic transfer hydrodrogenation,and enzymatic reduction with isolated protein or whole cells afford the 4-TMS-3-butyn- 2-ol with varying degrees of enantioenrichment.Enzymatic resolution by esterification of the racemic alcohol is the method of choice for the large-scale preparation.

4-TRIMETHYLSILYL-3-BUTYN-2-OL Preparation Products And Raw materials

Raw materials

propargyl aldehyde

Welcome！

Please leave a message for us or use the following ways to contact us, we will reply to you as soon as possible, and provide you with the most sincere service, thank you.

NO. 18 ,Wujiang Road, Wulidian Street, Jiangbei District, Chongqing
+86-23-6139-8061 +86-13650506873
danny@chemdad.com sales@chemdad.com
www.chemdad.com
WhatsApp +86-13650506873