METHYL ACETIMIDATE HYDROCHLORIDE

CAS No.：14777-27-6

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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METHYL ACETIMIDATE HYDROCHLORIDE Basic information

Product Name:	METHYL ACETIMIDATE HYDROCHLORIDE
Synonyms:	acetimidicacid,methylester,hydrochloride;ethanimidicacid,methylester,hydrochloride;METHYL ACETIMIDATE HCL;METHYL ACETIMIDATE HYDROCHLORIDE;METHYL ACETIMIDATE HYDROCHLORIDE, TECH.;AcetimidicacidmethylesterHCl;Methyl acetiMidate hydrochloride , Technical;Methyl acetimidate hydrochloride technical grade
CAS:	14777-27-6
MF:	C3H8ClNO
MW:	109.55
EINECS:	238-843-3
Product Categories:	Amidates/Imidates;Nitrogen Compounds;Organic Building Blocks
Mol File:	14777-27-6.mol

METHYL ACETIMIDATE HYDROCHLORIDE Chemical Properties

Melting point	105 °C (dec.)(lit.)
storage temp.	2-8°C
BRN	3671581
EPA Substance Registry System	Ethanimidic acid, methyl ester, hydrochloride (14777-27-6)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	AK2950000
F	10-21
HS Code	2929900090

MSDS Information

Provider	Language
SigmaAldrich	English

METHYL ACETIMIDATE HYDROCHLORIDE Usage And Synthesis

Chemical Properties	White to yellow powder
Uses	Methyl acetimidate hydrochloride has been used in pre-crystallization chemical modification of lysine residues.
General Description	Methyl acetimidate hydrochloride is an inhibitor of N-methylation of phosphatidylethanolamine. It also prevents the stimulation of purified cardiac sarcolemmal vesicles Ca²⁺-pump activities.
Purification Methods	Crystallise the imidate from methanol by adding dry ether to a ratio of 1:1 and cooling at 0o. Filter off the crystals in a cold room, wash them with methanol/ether (1:2), then dry in a vacuum. [Hunter & Ludwig J Am Chem Soc 84 3491 1962.] The free base has b 90-91o/765mm, d 0.867, n 1.403. [Hunter & Ludwig Methods Enzymol 25 585 1973, Beilstein 2 IV 181.]

METHYL ACETIMIDATE HYDROCHLORIDE Preparation Products And Raw materials

Preparation Products

Methyl N-cyanoethanimideate-->4-AMINO-2-METHYLPYRIMIDINE-5-CARBONITRILE

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