4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid

CAS No.：641569-94-0

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4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Basic information

Product Name:	4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid
Synonyms:	4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid;Nilotinib EP Impurity D;4-Methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid;Benzoic acid, 4-Methyl-3-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]-;4-Methyl-3-[[4-(3-pyridinyl)-2-pyriMidiny]aMino]benzoic acid;2-[(5-Carboxy-2-methylphenyl)amino]-4-(pyridin-3-yl)pyrimidine, 3-{2-[(5-Carboxy-2-methylphenyl)amino]pyrimidin-4-yl}pyridine;Nilotinib Intemediate 2;4-Methyl-3-((4-(pyridin-3-yl)
CAS:	641569-94-0
MF:	C17H14N4O2
MW:	306.32
EINECS:	629-968-8
Product Categories:
Mol File:	641569-94-0.mol

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Chemical Properties

Melting point	>257oC (dec.)
Boiling point	587.9±60.0 °C(Predicted)
density	1.336
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	DMSO (Slightly), Methanol (Slightly, Heated)
pka	4.35±0.10(Predicted)
form	Solid
color	Pale Beige
Stability:	Hygroscopic
CAS DataBase Reference	641569-94-0(CAS DataBase Reference)

Safety Information

HS Code

2933599590

MSDS Information

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Usage And Synthesis

Uses

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid is used in the preparation of (pyridinyl)-N-[(triazolyl)phenyl]pyrimidinamine derivatives and (pyridinyl)-N-[oxadiazolyl)phenyl]pyrimidinamine derivatives, and can be used in the detection of their activity as antileukemia agents (neoplastic stem cell leukemia). 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid is also a Nilotinib (N465300) intermediate, which might be useful in treatment of chronic myelogenous leukemia.

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Preparation Products And Raw materials

Raw materials

3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester-->Methyl 3-guanidino-4-Methylbenzoate-->Imatinib Impurity-->Methyl 3-amino-4-methylbenzoate-->3-Amino-4-methylbenzoic acid-->3-[(aMinoiMinoMethyl)aMino]-4-Methylbenzoic acid Methyl ester Mononitrate-->4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid methyl ester-->3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester mononitrate-->AKOS BB-3093-->3-Acetylpyridine-->3-Bromo-4-methylbenzoic acid

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