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| 5-Chloro-1-methyl-4-nitroimidazole Chemical Properties |
| Melting point | 148-150 °C (lit.) | | Boiling point | 362.3±22.0 °C(Predicted) | | density | 1.9518 (rough estimate) | | refractive index | 1.5500 (estimate) | | storage temp. | Inert atmosphere,2-8°C | | solubility | Chloroform (Slightly), Methanol (Slightly) | | pka | -1.37±0.61(Predicted) | | form | Powder | | color | White | | InChIKey | OSJUNMSWBBOTQU-UHFFFAOYSA-N | | CAS DataBase Reference | 4897-25-0(CAS DataBase Reference) | | NIST Chemistry Reference | 1H-imidazole, 5-chloro-1-methyl-4-nitro-(4897-25-0) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-37/39 | | WGK Germany | 3 | | RTECS | NI4397100 | | HazardClass | IRRITANT | | HS Code | 29332900 |
| 5-Chloro-1-methyl-4-nitroimidazole Usage And Synthesis |
| Description | 5-Chloro-1-methyl-4-nitroimidazole is an imidazole derivative. It is useful in the rapid mix experiments to investigate the mechanism of anomalous radiosensitization of mammalian cells. It can also be used in the synthesis of 5-aryl-1-methyl-4-nitroimidazoles, via Suzuki coupling with arylboronic acids, catalyzed by dichlorobis-(triphenylphosphine) palladium (II), K2CO3 and tetrabutylammonium bromide.
| | References | http://www.sigmaaldrich.com/catalog/product/aldrich/367532?lang=en®ion=US
Watts, M. E., et al. "Rapid-mix studies on the anomalous radiosensitization of mammalian cells by 5-chloro-1-methyl-4-nitromidazole." Int J Radiat Biol Relat Stud Phys Chem Med 38.6(1980):673-675.
Saadeh, H. A, I. M. Mosleh, and M. M. Elabadelah. "New synthesis and antiparasitic activity of model 5-aryl-1-methyl-4-nitroimidazoles. "Molecules 14.8(2009):2758-67.
| | Description | 5-Chloro-1-methyl-4-nitroimidazole is an intermediate
in azathioprine synthesis, also present in the end
product. It induced contact dermatitis in a man
working on azathioprine synthesis. Cross reactivity is
possible with imidazoles tioconazole, and econazole. | | Chemical Properties | White Solid | | Uses | 5-Chloro-1-methyl-4-nitroimidazole (CMNI) is suitable for use in the rapid mix experiments to investigate the mechanism of anomalous radiosensitization of mammalian cells by CMNI. It may be used in the synthesis of 5-aryl-1-methyl-4-nitroimidazoles, via Suzuki coupling with arylboronic acids, catalyzed by dichlorobis-(triphenylphosphine)palladium(II), K2CO3 and tetrabutylammonium bromide. | | General Description | 5-Chloro-1-methyl-4-nitroimidazole is an 4-nitroimidazole derivative. | | Contact allergens | This intermediate in azathioprine synthesis is also present
in the end product. It induced contact dermatitis in
a man working on azathioprine synthesis. Cross-reactivity
is possible with imidazoles tioconazole and
econazole. |
| 5-Chloro-1-methyl-4-nitroimidazole Preparation Products And Raw materials |
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