Other grades of this product :
| Tetrahydroberberine Basic information |
| Product Name: | Tetrahydroberberine | | Synonyms: | (13aR)-5,8,13,13a-Tetrahydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine;l-Canadine;l-Tetrahydroberberine;l-Xanthopuccine;6H-Benzo[G]-1,3-benzodioxolo[5,6-A]quinolizine, 5,8,13,13A-tetrahydro-9,10-dimethoxy-;Berberine, tetrahydro-;Berbine, 9,10-dimethoxy-2,3-(methylenedioxy)-;Nsc94918 | | CAS: | 522-97-4 | | MF: | C20H21NO4 | | MW: | 339.39 | | EINECS: | 208-338-2 | | Product Categories: | Inhibitors;reference standards from Chinese medicinal herbs (TCM).;chemical reagent;pharmaceutical intermediate;phytochemical;standardized herbal extract;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals | | Mol File: | 522-97-4.mol |
| Tetrahydroberberine Chemical Properties |
| Melting point | 166.5 °C | | Boiling point | 476.1±45.0 °C(Predicted) | | density | 1.33±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO: >10 mg/mL, soluble | | form | solid | | pka | 6.53±0.20(Predicted) | | color | yellow |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 36 | | WGK Germany | 3 | | Toxicity | LD50 in mice (mg/kg): 940 orally; 790 s.c.; 100 i.v. (Sadritdinov, Sultanov) |
| Tetrahydroberberine Usage And Synthesis |
| Uses | Tetrahydroberberine is a protoberberine alkaloid which potently block functional KATP channels natively expressed on midbrain dopamine neurons. Tetrahydroberberine is used for treatment of degenerative diseases or conditions associated with KATP channel signaling.
| | Uses | Canadine is a protoberberine alkaloid which potently block functional KATP channels natively expressed on midbrain dopamine neurons. Canadine is used for treatment of degenerative diseases or conditions associated with KATP channel signaling. | | Definition | ChEBI: A berberine alkaloid that is 5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline substituted by methoxy groups at positions 9 and 10. |
| Tetrahydroberberine Preparation Products And Raw materials |
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