(S)-1-Boc-3-hydroxypiperidine

CAS No.：143900-44-1

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

View the full Disclaimer

Other grades of this product :

(S)-1-Boc-3-hydroxypiperidine Basic information

Uses

Product Name:	(S)-1-Boc-3-hydroxypiperidine
Synonyms:	(S)-3-HYDROXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;(S)-3-HYDROXY-1-(TERT-BUTOXYCARBONYL)PIPERIDINE;(S)-1-BOC-3-HYDROXYPIPERIDINE;(S)-1-BOC-3-PIPERIDINOL;(S)-N-(TERT-BUTOXYCARBONYL)-3-HYDROXYPIPERIDINE HYDROCHLORIDE;(S)-N-BOC-3-HYDROXY PIPERIDINE;(S)-TERT BUTYL-3-HYDROXYPIPERIDINE-1-CARBOXYLATE;1-PIPERIDINECARBOXYLIC ACID, 3-HYDROXY-, 1,1-DIMETHYLETHYL ESTER, (3S)-
CAS:	143900-44-1
MF:	C10H19NO3
MW:	201.26
EINECS:
Product Categories:	Piperazine;Chiral Reagents;Piperidines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Anticancer;143900-44-1
Mol File:	143900-44-1.mol

(S)-1-Boc-3-hydroxypiperidine Chemical Properties

Melting point	34-40 °C
Boiling point	292.3±33.0 °C(Predicted)
density	1.107±0.06 g/cm3(Predicted)
Fp	110 °C
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in methanol.
pka	14.74±0.20(Predicted)
form	Powder or Crystalline Powder
color	White to tan
optical activity	[α]22/D +10.0°, c = 1 in chloroform
InChIKey	UIJXHKXIOCDSEB-QMMMGPOBSA-N
CAS DataBase Reference	143900-44-1(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36/37/39
WGK Germany	3
HS Code	29339900

MSDS Information

(S)-1-Boc-3-hydroxypiperidine Usage And Synthesis

Uses	(S)-1-Boc-3-hydroxypiperidine is an important chiral intermediate for the synthesis of ibrutinib, an anticancer drug targeting B-cell malignancies. Synthesis of pharmaceutical intermediates including ibrutinib, the API of the newly approved drug Imbruvica, for the treatment of lymphoma.
Chemical Properties	White powder
Uses	A piperidine derivative with an amine protecting group, (S)-1-Boc-3-hydroxypiperidine can be used in the preparation of biologically active compounds such as antagonists of the human P2X7 receptor and selective irreversible inhibitors for bruton's tyrosine kinase.
Uses	(S)-1-Boc-3-hydroxypiperidine is used as pharmaceutical intermediate.

(S)-1-Boc-3-hydroxypiperidine Preparation Products And Raw materials

Preparation Products

(S)-3-Hydroxypiperidine hydrochloride-->(3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine-->(S)-3-Methoxypiperidine

Welcome！

Please leave a message for us or use the following ways to contact us, we will reply to you as soon as possible, and provide you with the most sincere service, thank you.

NO. 18 ,Wujiang Road, Wulidian Street, Jiangbei District, Chongqing
+86-23-6139-8061 +86-13650506873
danny@chemdad.com sales@chemdad.com
www.chemdad.com
WhatsApp +86-13650506873