(S)-1-Boc-3-hydroxypiperidine Nine Chongqing Chemdad Co. ，Ltd

Product

(S)-1-Boc-3-hydroxypiperidine

CAS No.：143900-44-1

Other grades of this product :

(S)-1-Boc-3-hydroxypiperidine Basic information

Product Name:	(S)-1-Boc-3-hydroxypiperidine
Synonyms:	(S)-3-HYDROXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;(S)-3-HYDROXY-1-(TERT-BUTOXYCARBONYL)PIPERIDINE;(S)-1-BOC-3-HYDROXYPIPERIDINE;(S)-1-BOC-3-PIPERIDINOL;(S)-N-(TERT-BUTOXYCARBONYL)-3-HYDROXYPIPERIDINE HYDROCHLORIDE;(S)-N-BOC-3-HYDROXY PIPERIDINE;(S)-TERT BUTYL-3-HYDROXYPIPERIDINE-1-CARBOXYLATE;1-PIPERIDINECARBOXYLIC ACID, 3-HYDROXY-, 1,1-DIMETHYLETHYL ESTER, (3S)-
CAS:	143900-44-1
MF:	C10H19NO3
MW:	201.26
EINECS:
Product Categories:	Piperazine;Chiral Reagents;Piperidines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Anticancer;143900-44-1
Mol File:	143900-44-1.mol

(S)-1-Boc-3-hydroxypiperidine Chemical Properties

Melting point	34-40 °C
Boiling point	292.3±33.0 °C(Predicted)
density	1.107±0.06 g/cm3(Predicted)
Fp	110 °C
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in methanol.
pka	14.74±0.20(Predicted)
form	Powder or Crystalline Powder
color	White to tan
optical activity	[α]22/D +10.0°, c = 1 in chloroform
InChIKey	UIJXHKXIOCDSEB-QMMMGPOBSA-N
CAS DataBase Reference	143900-44-1(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36/37/39
WGK Germany	3
HS Code	29339900

MSDS Information

(S)-1-Boc-3-hydroxypiperidine Usage And Synthesis

Uses	(S)-1-Boc-3-hydroxypiperidine is an important chiral intermediate for the synthesis of ibrutinib, an anticancer drug targeting B-cell malignancies. Synthesis of pharmaceutical intermediates including ibrutinib, the API of the newly approved drug Imbruvica, for the treatment of lymphoma.
Chemical Properties	White powder
Uses	A piperidine derivative with an amine protecting group, (S)-1-Boc-3-hydroxypiperidine can be used in the preparation of biologically active compounds such as antagonists of the human P2X7 receptor and selective irreversible inhibitors for bruton's tyrosine kinase.
Uses	(S)-1-Boc-3-hydroxypiperidine is used as pharmaceutical intermediate.

(S)-1-Boc-3-hydroxypiperidine Preparation Products And Raw materials

Preparation Products

(S)-3-Hydroxypiperidine hydrochloride-->(3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine-->(S)-3-Methoxypiperidine

Welcome！

Please leave a message for us or use the following ways to contact us, we will reply to you as soon as possible, and provide you with the most sincere service, thank you.

NO. 18 ,Wujiang Road, Wulidian Street, Jiangbei District, Chongqing
+86-23-6139-8061 +86-13650506873
danny@chemdad.com sales@chemdad.com
www.chemdad.com
WhatsApp +86-13650506873