Product

2-Methylindole-3-carboxaldehyde

CAS No.：5416-80-8

Other grades of this product :

2-Methylindole-3-carboxaldehyde Basic information

Product Name:	2-Methylindole-3-carboxaldehyde
Synonyms:	2-methyl-1h-indole-3-carboxaldehyd;AKOS BBS-00000868;AKOS JY2083591;AKOS 233-93;2-METHYLINDOLE-3-CARBALDEHYDE;2-METHYLINDOLE-3-CARBOXALDEHYDE;2-METHYLINDOLE-3-CARBOXYALDEHYDE;2-METHYL-1H-INDOLE-3-CARBALDEHYDE
CAS:	5416-80-8
MF:	C10H9NO
MW:	159.18
EINECS:	226-512-6
Product Categories:	Heterocycle-Indole series;Aldehydes;Building Blocks;C10;C10-C12;Carbonyl Compounds;ALDEHYDE;Indoles;Simple Indoles;Building Blocks;Heterocyclic Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Organic Building Blocks;Indoles and derivatives
Mol File:	5416-80-8.mol

2-Methylindole-3-carboxaldehyde Chemical Properties

Melting point	200-201 °C (lit.)
Boiling point	344.3±22.0 °C(Predicted)
density	1.226±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	soluble in Methanol
pka	16.08±0.30(Predicted)
form	Powder
color	Brown
CAS DataBase Reference	5416-80-8(CAS DataBase Reference)
EPA Substance Registry System	1H-Indole-3-carboxaldehyde, 2-methyl- (5416-80-8)

Safety Information

Hazard Codes	Xi,Xn
Risk Statements	36/37/38-22
Safety Statements	37/39-26
WGK Germany	3
HazardClass	IRRITANT
HS Code	29339900

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English

2-Methylindole-3-carboxaldehyde Usage And Synthesis

Chemical Properties	Brown powder
Uses	Reactant for preparation of:• ;Tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators1• ;Fluorescent sensors (BODIPY)2• ;Antimicrobial agents against methicillin-resistant Staphylococcus aureus3• ;G protein-coupled receptor CRTh2 antagonists4• ;Inhibitors of PI3 kinase-α5• ;Antitubercular agents6• ;Anti-inflammatory agents7• ;Mycobacterium tuberculosis protein tyrosine phosphatase B8• ;Glucocorticoid receptor ligands9• ;Agents stimulating neurite outgrowth10
Uses	Reactant for preparation of: Tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators Fluorescent sensors (BODIPY) Antimicrobial agents against methicillin-resistant Staphylococcus aureus G protein-coupled receptor CRTh2 antagonists Inhibitors of PI3 kinase-α Antitubercular agents Anti-inflammatory agents Mycobacterium tuberculosis protein tyrosine phosphatase B Glucocorticoid receptor ligands Agents stimulating neurite outgrowth
Synthesis Reference(s)	Chemical and Pharmaceutical Bulletin, 31, p. 2892, 1983 DOI: 10.1248/cpb.31.2892
General Description	Oxidative activation of 2-methylindole-3-carboxaldehyde via N-heterocyclic carbene organocatalysis generates heterocyclic ortho-quinodimethane as a key intermediate.

2-Methylindole-3-carboxaldehyde Preparation Products And Raw materials

Preparation Products

2-METHYLINDOLE-3-ACETIC ACID-->N-Acetylanthranilic acid

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