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| 5-Chlorouracil Basic information |
| Product Name: | 5-Chlorouracil | | Synonyms: | TIMTEC-BB SBB004103;2,4(1H,3H)-Pyrimidinedione,5-chloro-;2,4-Pyrimidinediol,5-chloro-;3h)-pyrimidinedione,5-chloro-4(1h;5-Chloro-1,2,3,4-tetrahydropyrimidine-2,4-dione;5-Chloropyrimidine-2,4-diol;5-Chlorouracil,99%;Fluorouracil Related CoMpound E | | CAS: | 1820-81-1 | | MF: | C4H3ClN2O2 | | MW: | 146.53 | | EINECS: | 217-339-7 | | Product Categories: | Pyrimidine series;Heterocyclic Compounds;Biochemistry;Nucleobases and their analogs;Nucleosides, Nucleotides & Related Reagents;Nucleic acids;PYRIMIDINE;Pyridines, Pyrimidines, Purines and Pteredines;Bases & Related Reagents;Heterocycles;Nucleotides | | Mol File: | 1820-81-1.mol |
| 5-Chlorouracil Chemical Properties |
| Melting point | >300 °C (lit.) | | density | 1.6838 (rough estimate) | | refractive index | 1.6550 (estimate) | | storage temp. | 2-8°C | | solubility | 1 M NH4OH: soluble50mg/mL | | pka | 6.77±0.10(Predicted) | | form | Solid | | color | White to Off-White | | Water Solubility | 2.501g/L(25 ºC) | | BRN | 127173 | | InChIKey | ZFTBZKVVGZNMJR-UHFFFAOYSA-N | | CAS DataBase Reference | 1820-81-1(CAS DataBase Reference) | | EPA Substance Registry System | 5-Chlorouracil (1820-81-1) |
| 5-Chlorouracil Usage And Synthesis |
| Chemical Properties | white to light beige crystalline powder | | Uses | 5-Chlorouracil was used as a control in resazurin-based cytotoxicity assay for screening of cytotoxicity in hepatocytes and liver cell lines. | | Uses | 5-Chlorouracil can be used for the experimental and clinical treatment of neoplastic and viral diseases.
| | Definition | ChEBI: An organochlorine compound consisting of uracil having an chloro substituent at the 5-position. | | General Description | The shape resonance spectra of 5-chlorouracil, obtained from fixed-nuclei elastic scattering calculations by the Schwinger multichannel method with pseudopotentials, was studied. | | Purification Methods | It recrystallises from hot H2O (4g/500mL) using charcoal. [McOmie et al. J Chem Soc 3478 1955, West & Barrett J Am Chem Soc 76 3146 1954, Beilstein 24 III/IV 1231.] |
| 5-Chlorouracil Preparation Products And Raw materials |
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