Phlorizin dihydrate

CAS No.：7061-54-3

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Phlorizin dihydrate Basic information

Product Name:	Phlorizin dihydrate
Synonyms:	Phlorizin dihydrate 1-[2-(beta-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone dihydrate;1-[2,4-dihydroxy-6-[[3,4,5-trihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]phenyl]-3-(4-hydroxyphenyl)-1-propanone dihydrate;2'-O-GLUCOSYL-4',6',4-TRIHYDROXYDIHYDROCHALCONE;1-[2-(beta-d-glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone dihydrate;TIMTEC-BB SBB005924;PHLORETIN-2'-BETA-D-GLUCOSIDE;PHLORIDZIN;phloridzin from apple wood
CAS:	7061-54-3
MF:	C21H24O10
MW:	436.41
EINECS:	628-113-6
Product Categories:	Natural Plant Extract
Mol File:	7061-54-3.mol

Phlorizin dihydrate Chemical Properties

Melting point	113-114 °C(lit.)
alpha	-52 º (c=3, EtOH)
storage temp.	Inert atmosphere,2-8°C
form	neat
optical activity	[α]20/D 52°, c = 3 in ethanol
BRN	66621
CAS DataBase Reference	7061-54-3(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
RTECS	UC2080000
F	3-10-23

MSDS Information

Phlorizin dihydrate Usage And Synthesis

Uses

Phloridzin dihydrate has been used as:

a Na^+-glucose cotransport inhibitor to test its effect in lowering blood glucose
a hexose carrier inhibitor to prevent glucose derivative 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose (2-NBDG) uptake in sycamore cells
a non-specific sodium-glucose co-transporter 2 (SGLT2) inhibitor in embryonic cardiomyocyte cell line H9C2 to investigate its protective effect on Dox-induced cytotoxicity

Biochem/physiol Actions

Phloridzin is a glycoside present in the leaves and bark of apple. It is also present in peel and pulp of the apple fruit. Phloridzin belongs to the dihydrochalcones class of compounds. Lactase catabolizes phloridzin to phloretin and glucose in small intestine epithelial cells. Phloridzin is an antidiabetic agent and is equally bioavailable as phloretin.

Phlorizin dihydrate Preparation Products And Raw materials

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