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| 2-Amino-1,3,4-thiadiazole Basic information |
| Product Name: | 2-Amino-1,3,4-thiadiazole | | Synonyms: | 5-nitro-1,3,4-thiadiazol-2-aMine;2-AMino-1,3,4-thiadiazole, 97% 10GR;5-AMino-1,3,4-thiadiazole;2-AMino-1,3,4-thiadiazole 97%;1,3,4-Thiadiazole, 2-amino-;1,3,4-Thiadiazole-2-Amine;2-Amino-1-thia-3,4-diazole;2-Aminothiadiazole | | CAS: | 4005-51-0 | | MF: | C2H3N3S | | MW: | 101.13 | | EINECS: | 223-657-7 | | Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;VARIOUSAMINE;Amines;Oxadiazoles & Thiadiazoles;Sulfur & Selenium Compounds;Oxadiazoles & Thiadiazoles;Thiazole;API intermediates;Aromatic;Heterocycles;bc0001 | | Mol File: | 4005-51-0.mol |
| 2-Amino-1,3,4-thiadiazole Chemical Properties |
| Melting point | 188-191 °C (dec.) (lit.) | | Boiling point | 238.9±23.0 °C(Predicted) | | density | 1.385 (estimate) | | refractive index | 1.5800 (estimate) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | water: soluble25mg/mL, clear, colorless | | form | Crystals or Crystalline Powder | | pka | pKa 3.2 (Uncertain) | | color | White to light yellow | | Water Solubility | It is soluble in water, hot methanol- very faint turbidity. | | BRN | 107135 | | InChIKey | QUKGLNCXGVWCJX-UHFFFAOYSA-N | | CAS DataBase Reference | 4005-51-0(CAS DataBase Reference) | | NIST Chemistry Reference | 2-Amino-1,3,4-thiadiazole(4005-51-0) |
| Hazard Codes | Xn,Xi | | Risk Statements | 68-63-36/37/38-20/21/22-22 | | Safety Statements | 36/37/39-26-36 | | RIDADR | 2811 | | WGK Germany | 3 | | RTECS | XI3000000 | | Hazard Note | Harmful | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29349990 | | Toxicity | LD50 oral in rat: 253mg/kg |
| 2-Amino-1,3,4-thiadiazole Usage And Synthesis |
| Chemical Properties | white to light yellow crystal powde | | Uses | A thiadiazole derivative with fungacidal properties. An antitumor agent. | | Uses | 2-Amino-1,3,4-thiadiazole, is used as an intermediate for ceftraoline. | | General Description | 2-Amino-1,3,4-thiadiazole (donor) form charge transfer complexes with 2,3-dichloro-5,6-dicyano-p-benzoquinone, p-chloranil, o-chloranil, p-bromanil and chloranilic acid (acceptors). Effects of 2-amino-1,3,4-thiadiazole [aminothiadiazole (NSC 4728)] on purine and pyrimidine ribonucleotide pools of L1210 ascites cells in vivo has been reported. | | Safety Profile | Poison by subcutaneous andintraperitoneal routes. An experimental teratogen. Otherexperimental reproductive effects. When heated todecomposition it emits very toxic fumes of NOx and SOx. |
| 2-Amino-1,3,4-thiadiazole Preparation Products And Raw materials |
| Raw materials | Hydrazinecarboxamide, 2-formyl--->Methanimidic acid ethyl ester-->Methanone, (5-amino-1,3,4-thiadiazol-2-yl)phenyl--->Benzamide, N-1,3,4-thiadiazol-2-yl--->Formamide, N-1,3,4-thiadiazol-2-yl--->Methanimidamide,N,N'-di-1,3,4-thiadiazol-2-yl--->CL 19506 7-5526-->1-formylthiosemicarbazide-->thiosemicarbazide-->Formic acid | | Preparation Products | 2-AMINO-5-BROMO-[1,3,4]THIADIAZOLE-->2-Mercapto-1,3,4-thiadiazol |
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