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| Aripiprazole Lauroxil Basic information |
| Product Name: | Aripiprazole Lauroxil | | Synonyms: | 1259305-29-7.;Aripiprazole Lauroxil;Dodecanoic acid [7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2-oxo-1(2H)-quinolinyl]methyl ester;RDC 3317 | | CAS: | 1259305-29-7 | | MF: | C36H51Cl2N3O4 | | MW: | 660.71 | | EINECS: | 826-270-7 | | Product Categories: | API | | Mol File: | 1259305-29-7.mol |
| Aripiprazole Lauroxil Chemical Properties |
| Melting point | 83 - 84°C | | Boiling point | 781.7±60.0 °C(Predicted) | | density | 1.153±0.06 g/cm3(Predicted) | | storage temp. | Refrigerator, under inert atmosphere | | solubility | Chloroform (Slightly), Methanol (Slightly, Sonicated) | | form | Solid | | pka | 7.67±0.10(Predicted) | | color | White to Off-White |
| Aripiprazole Lauroxil Usage And Synthesis |
| Description | Aripiprazole
lauroxil is a long acting injectable (LAI) pro-drug formulation
of aripiprazole approved in the U.S. for the treatment of
schizophrenia. Aripiprazole lauroxil is a dopamine D2
receptor partial antagonist, a 5-HT2A antagonist, and a 5-
HT1A partial agonist that was developed by Alkermes. It was Aripiprazole
lauroxil is a long acting injectable (LAI) pro-drug formulation
of aripiprazole approved in the U.S. for the treatment of
schizophrenia.28 Aripiprazole lauroxil is a dopamine D2
receptor partial antagonist, a 5-HT2A antagonist, and a 5-
HT1A partial agonist that was developed by Alkermes. It was | | Definition | ChEBI: A dodecanoate ester obtained by formal condensation of the carboxy group of dodecanoic acid with the hydroxy group of 7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-2-oxo-3,4-dihydroquinolin-1(2H)-yl]methanol. A prodrug for aripipraz
le, it is used for treatment of schizophrenia. | | Synthesis | The synthesis of aripiprazole lauroxil has only been described
on gram scale in the patent literature. Commercially available aripiprazole (58) was
treated with formaldehyde to give hemiaminal 59 in 65% crude
yield and was then heated with lauric anhydride to give
aripiprazole lauroxil (VII) in 21% overall yield. |
| Aripiprazole Lauroxil Preparation Products And Raw materials |
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