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| Spermine Basic information |
| Product Name: | Spermine | | Synonyms: | SPERMINE TETRAHYDROCHLORIDE;SPERMINE HYDROCHLORIDE;n,n’-bis(3-aminopropyl)-4-butanediamine;n,n’-bis(3-aminopropyl)-4-diaminobutane;Spermin;N,N'-BIS(3-AMINOPROPYL)-1,4-BUTANEDIAMINE 4 H CL;N,N'-BIS(3-AMINOPROPYL)-1,4-BUTANEDIAMINE TETRAHYDROCHLORIDE;N,N'-BIS-(3-AMINOPROPYL)-1,4-DIAMINOBUTANE TETRAHYDROCHLORIDE | | CAS: | 71-44-3 | | MF: | C10H26N4 | | MW: | 202.34 | | EINECS: | 200-754-2 | | Product Categories: | Aliphatics;Amines;Glutamate;co-factor;Inhibitors;Elisa Kit-Mouse Elisa Kit | | Mol File: | 71-44-3.mol |
| Spermine Chemical Properties |
| Melting point | 28-30 (lit.) | | Boiling point | 150 °C/5 mmHg (lit.) | | density | 0.937 | | refractive index | 1.4850 (estimate) | | Fp | >230 °F | | storage temp. | 2-8°C | | solubility | H2O: 1 M at 20 °C, clear, colorless | | form | powder | | pKa | 10.88±0.19(Predicted) | | Water Solubility | Soluble in chloroform, methanol, water and lower alcohols. Insoluble in ether, benzene and petroleum ether. | | Sensitive | Air Sensitive & Hygroscopic | | Merck | 14,8743 | | BRN | 1751791 | | InChIKey | PFNFFQXMRSDOHW-UHFFFAOYSA-N | | CAS DataBase Reference | 71-44-3(CAS DataBase Reference) | | NIST Chemistry Reference | Spermine(71-44-3) | | EPA Substance Registry System | 1,4-Butanediamine, N,N'-bis(3-aminopropyl)- (71-44-3) |
| Hazard Codes | Xi,C | | Risk Statements | 36/38-34 | | Safety Statements | 26-36-45-36/37/39-27 | | RIDADR | UN 3259 8/PG 2 | | WGK Germany | 3 | | RTECS | EJ7230000 | | F | 3-10 | | TSCA | Yes | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29212900 |
| Spermine Usage And Synthesis |
| Description | Spermine is an endogenous polyamine synthesized from the reaction of spermidine with decarboxylated S-adenosylmethionine in the presence of the enzyme spermine synthase and is required for eukaryotic cell growth and protein synthesis. Intracellular spermine blocks inward rectifying K+ channels, whereas extracellular spermine acts as a mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Spermine has neuroprotective and anti-inflammatory effects and functions as a free radical scavenger to prevent DNA damage by reactive oxygen species. | | Chemical Properties | White to slightly off-white powder crysta | | Uses | immune modulator | | Uses | Binds to the polyamine modulatory site of NMDA Spermine is essential for both normal and neoplastic tissue growth. It is involved in the modulation of calcium-dependent immune processes. It plays an important role in cellular proliferation and differentiation as well as inhibits neuronal nitric oxide synthase (nNOS). | | Uses | Biogenic polyamine formed from spermidine and occurring in almost all tissues. Essential for both normal and neoplastic tissue growth. Involved in the modulation of calcium-dependent immune processes | | Definition | ChEBI: A polyazaalkane that is tetradecane in which the carbons at positions 1, 5, 10 and 14 are replaced by nitrogens. Spermine has broad actions on cellular metabolism. | | General Description | Spermine?is a polyamine, which functions as a free radical scavenger. It modulates gene expression, chromatin stabilization and prevents DNA damage. Spermine inhibits endonuclease-mediated DNA fragmentation. | | Biochem/physiol Actions | Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS). | | references | [1] fakler b, brndle u, glowatzki e, et al. strong voltage-dependent inward rectification of inward rectifier k+ channels is caused by intracellular spermine[j]. cell, 1995, 80(1): 149-154.[2] til h p, falke h e, prinsen m k, et al. acute and subacute toxicity of tyramine, spermidine, spermine, putrescine and cadaverine in rats[j]. food and chemical toxicology, 1997, 35(3): 337-348. |
| Spermine Preparation Products And Raw materials |
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