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| 6-Maleimidocaproic acid Basic information |
| 6-Maleimidocaproic acid Chemical Properties |
| Melting point | 86-91 °C | | Boiling point | 407.3±28.0 °C(Predicted) | | density | 1.285±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO (Slightly), Ethyl Acetate (Slightly) | | pka | 4.74±0.10(Predicted) | | form | Powder | | color | White to pale yellow | | Water Solubility | Soluble in water, methanol, ethanol, dimethyl sulfoxide. Insoluble in ether. | | Sensitive | Moisture Sensitive | | BRN | 1532405 | | InChIKey | WOJKKJKETHYEAC-UHFFFAOYSA-N | | CAS DataBase Reference | 55750-53-3(CAS DataBase Reference) | | EPA Substance Registry System | 1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo- (55750-53-3) |
| 6-Maleimidocaproic acid Usage And Synthesis |
| Description | 6-Maleimidocaproic acid contains a maleimide group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. | | Chemical Properties | White to yellow solid, powder, crystals or crystaline powder. | | Uses | 6-Maleimidohexanoic acid is used as a probe for introducing maleimides groups into biomolecules and active pharmaceutical ingredients. Further, it is used with N-hydroxysuccinimide ester as a bifunctional cross-linking reagent. In addition to this, it acts as a probe for thiol groups in membrane proteins. | | Definition | ChEBI: 6-Maleimidocaproic acid is a medium-chain fatty acid. It contains a maleimide group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. | | Application | 6-Maleimidocaproic acid is a sulfhydryl reactive heterobifunctional crosslinking reagent. It can be widely used probe for introducing maleimides groups into biomolecules. A probe for thiol groups in proteins. Spacer Arm: 9.4 Angstroms. Probe for thiol groups (SH-groups) in membrane proteins. |
| 6-Maleimidocaproic acid Preparation Products And Raw materials |
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