(S)-3-Hydroxy-gamma-butyrolactone

CAS No.：7331-52-4

Other grades of this product :

(S)-3-Hydroxy-gamma-butyrolactone Basic information

Product Name:	(S)-3-Hydroxy-gamma-butyrolactone
Synonyms:	2(3H)-FURANONE, DIHYDRO-3-HYDROXY-, (S);2(3H)-FURANONE, DIHYDRO-4-HYDROXY-, (S);(S)-4-HYDROXYTETRAHYDROFURAN-2-ONE;(S)-4,5-DIHYDRO-4-HYDROXY-2(3H)-FURANONE;(S)-(-)-3-HYDROXYBUTYROLACTONE;(S)-3-HYDROXYBUTYROLACTONE;(S)-(-)-3-HYDROXY-GAMA-BUTYROLACTONE;(S)-(-)-3-HYDROXY-GAMMA-BUTYROLACTONE
CAS:	7331-52-4
MF:	C4H6O3
MW:	102.09
EINECS:	434-990-4
Product Categories:	Chiral Building Blocks;Simple Alcohols (Chiral);chiral;Tetrahydrofuran Series;Synthetic Organic Chemistry;7331-52-4
Mol File:	7331-52-4.mol

(S)-3-Hydroxy-gamma-butyrolactone Chemical Properties

Boiling point	98-100 °C0.3 mm Hg(lit.)
density	1.241 g/mL at 25 °C(lit.)
refractive index	n20/D 1.464(lit.)
Fp	>230 °F
storage temp.	Inert atmosphere,2-8°C
pka	12.87±0.20(Predicted)
optical activity	[α]21/D 81°, c = 2 in ethanol
Water Solubility	Miscible with water, alcohol and other organic solvent. Immiscible with light petroleum.
BRN	1280864
CAS DataBase Reference	7331-52-4(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-37/39
WGK Germany	3
F	3-10
HS Code	29322090

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English
ALFA	English

(S)-3-Hydroxy-gamma-butyrolactone Usage And Synthesis

Description	(S)-3-Hydroxy-gamma-butyrolactone is an important intermediate in organic synthesis and an important chiral pool. It is mainly used in the synthesis of some natural products and some bioactive chiral drugs or antibiotic chiral drugs. For example, it is a key intermediate in synthesis of nerve regulator (R)-GABOB and brain metabolic accelerant S-oxiracetam (S-ORC). It can be deoxidized to (S)-(+)-3-Hydroxytetrahydrofuran which is an important intermediate of anti-AIDS drugs. It is also used in the synthesis of S(-)-3-hydroxy-4-bromobutyric acid which is a potential stabilizer.
Chemical Properties	Colorless to light yellow liquid.
Uses	(S)-3-Hydroxy-γ-butyrolactone can be used as an anticancer drug resistance inhibitor.
Precautions	For best results, Store in cool, dry place in tightly closed containers, under inert gas and protected from moisture as this substance is moisture sensitive. (S)-3-Hydroxy-gamma-butyrolactone is incompatible with oxidizing agents. This chemical causes skin irritation and serious eye irritation.

(S)-3-Hydroxy-gamma-butyrolactone Preparation Products And Raw materials

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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