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| ISOTETRANDRINE Basic information |
| Product Name: | ISOTETRANDRINE | | Synonyms: | 1-isotetrandrine;6,6’,7,12-tetramethoxy-2,2’-dimethyl-berbama;isosinomenina;isosinomeninea;o,o’-dimethylobamegine;o,o’-dimethylstepholine;O-METHYLBERBAMINE;BERBAMINE METHYL ETHER | | CAS: | 477-57-6 | | MF: | C38H42N2O6 | | MW: | 622.76 | | EINECS: | | Product Categories: | Alkaloids | | Mol File: | 477-57-6.mol |
| ISOTETRANDRINE Chemical Properties |
| Melting point | 180-182℃ | | Boiling point | 710.5±60.0 °C(Predicted) | | density | 1.172 | | RTECS | NX7285000 | | form | Off-white solid. | | pka | 7.70±0.20(Predicted) |
| ISOTETRANDRINE Usage And Synthesis |
| Description | A bisbenzylisoquinoline alkaloid, shown to be identical with berbamine methyl
ether, this base occurs in A therosperrna rnoschaturn, Berberis japonica and
Stephania cephalantha. It is dextrorotatory with [α]17D + 146° or[α]20D +
150.7° (c 0.85, CHC13). When recrystallized from MeOH it forms colourless
crystals and furnishes a crystalline dimethiodide, m.p. 242°C. Four methoxyl
groups and two methylimino groups are present. | | Uses | Isotetrandrine is a biscoclaurine alkaloid inhibitor of G protein activation of PLA2. | | References | Kondo et al., J. Pharrn. Soc., Japan, 58,920 (1938)Tomita, Fujita, Morai., ibid, 71,226,301 (1951)Bick, Clezy, Crow., Austral. J. Chern., 9, III (1956)Synthesis:Inubushi et ai., Tetrahedron Lett., 3399 (1968) |
| ISOTETRANDRINE Preparation Products And Raw materials |
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