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| Product Name: | Piroctone olamine | | Synonyms: | 2(1H)-Pyridinone,1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-,compd.with2-aminoethanol(1:1);4,4-trimethylpentyl)-1-hydroxy-4-methyl-6-(compd.with2-2(1h)-pyridinon;octopiroxolamine;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1h)-pyridinoncompd.with2-aminoethanol(1:1);Hydroxyl pyrazole ketones;1-Hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine;1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl);-one compound with 2-aminoethanol (1:1) | | CAS: | 68890-66-4 | | MF: | C16H30N2O3 | | MW: | 298.43 | | EINECS: | 272-574-2 | | Product Categories: | bacteriostatic and fungistatic;ARAMINE;OLED materials,pharm chemical,electronic;PP;68890-66-4 | | Mol File: | 68890-66-4.mol |
| Piroctone olamine Chemical Properties |
| Melting point | 134.0 to 138.0 °C | | Boiling point | 135-235℃[at 101 325 Pa] | | density | 1.1[at 20℃] | | vapor pressure | 0-0Pa at 20-25℃ | | storage temp. | Inert atmosphere,2-8°C | | solubility | Chloroform (Slightly, Sonicated), Methanol (Slightly) | | pka | 5.9-7.4[at 20 ℃] | | form | neat | | color | White to Off-White | | Water Solubility | 400-50000mg/L at 20-25℃ | | Merck | 14,7502 | | InChIKey | BTSZTGGZJQFALU-UHFFFAOYSA-N | | LogP | 1.05-3.86 at 20-25℃ | | CAS DataBase Reference | 68890-66-4(CAS DataBase Reference) |
| WGK Germany | 2 | | RTECS | UU7786150 | | HS Code | 2933399090 |
| Piroctone olamine Usage And Synthesis |
| Description | Piroctone olamine (INN; also known as piroctone ethanolamine; brand name Octopirox) is a compound sometimes used in the treatment of fungal infections.Piroctone olamine is the ethanolamine salt of the hydroxamic acid derivative piroctone.
| | Appearance | White or slightly yellow crystalline powder.
| | Solubility | Freely soluble in 10% ethanol in water; soluble in solution containing surfactants in water or in 1%-10% ethanol; slightly soluble in water and in oil. The solubility in water varies by pH value, and is a litter larger in neutral or weak basic solution than in acid solution.
| | Toxicity | Acute toxicity : Acute oral LD50 –rat 8100mg/kg, practically nontoxic.
Subchronic toxicity : NOEL: 100mg//kg/d (rat, orally, 3 months).
Chronic toxicity and carcinogencity : Negative.
Mutagenicity : Negative.
Irritation to skin and eye : Very low.
| | Uses | Piroctone olamine is used in combination with other substances as a part of shampoo effectively reduced the amount of dandruff and, at the same time, provided hair conditioning advantages. Recently was shown, that piroctone olamine could induce apoptosis and possessed a significant in vivo effect against myeloma.
| | Uses | Piroctone Olamine is an anti-dandruff agent used in shampoo formulations. | | Definition | ChEBI: An organoammonium salt that is the ethanolamine salt of piroctone. | | Brand name | Octopirox (Hoechst AG, Germany). |
| Piroctone olamine Preparation Products And Raw materials |
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