Product

3'-BROMO-4'-METHYLACETOPHENONE

CAS No.：40180-80-1

Other grades of this product :

3'-BROMO-4'-METHYLACETOPHENONE Basic information

Product Name:	3'-BROMO-4'-METHYLACETOPHENONE
Synonyms:	1-(3-BroMo-4-Methylphenyl)ethanone;3'-Bromo-4'-methylacetophenone 97%;1-(3-Bromo-4-methylphenyl)ethan-1-one;SIPO-022;3'-BROMO-4'-METHYLACETOPHENONE;Siponimod Impurity 1;Ethanone, 1-(3-bromo-4-methylphenyl)-;Fluralaner-004
CAS:	40180-80-1
MF:	C9H9BrO
MW:	213.07
EINECS:
Product Categories:	Bromine Compounds;C9;Aromatic Acetophenones & Derivatives (substituted);Adehydes, Acetals & Ketones;Carbonyl Compounds;Ketones
Mol File:	40180-80-1.mol

3'-BROMO-4'-METHYLACETOPHENONE Chemical Properties

Melting point	42-46 °C(lit.)
Boiling point	118°C/3mmHg(lit.)
density	1.388±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
color	Off-White to Pale Yellow

Safety Information

WGK Germany	3
HS Code	2914390090

MSDS Information

Provider	Language
SigmaAldrich	English

3'-BROMO-4'-METHYLACETOPHENONE Usage And Synthesis

Uses

3''-Bromo-4''-methylacetophenone is used as a starting material in the synthesis of mansonone E which is used to make mansonone E dervivatives. These derivatives are potent inhibitors of topoisomerase II (Topo II) and topoisomerase I (Topo I) and are also potent antitumor agents. 3''-Bromo-4''-methylacetophenone is also used as a reagent in the synthesis of BAF312, Siponimod which has been tested in the treatment of patients suffering from relapsing-remitting multiple sclerosis.

3'-BROMO-4'-METHYLACETOPHENONE Preparation Products And Raw materials

Raw materials

Benzenemethanol, 3-bromo-α,4-dimethyl--->Benzenemethanol, α-(bromomethyl)-4-methyl--->Ethanone, 1-(3-amino-4-methylphenyl)- (9CI)-->2-BROMO-P-CYMENE-->4-Methyl-3-nitroacetophenone-->2-Bromo-4'-methylacetophenone-->1-(4-Methylphenyl)ethanol-->4'-Methylacetophenone

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