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| Pyridoxal 5'-phosphate monohydrate Basic information |
| Pyridoxal 5'-phosphate monohydrate Chemical Properties |
| Melting point | 140-143 °C(lit.) | | storage temp. | 2-8°C | | solubility | Acetonitrile (Slightly), DMSO (Slightly) | | form | Crystalline Powder | | color | Pale yellow | | Water Solubility | 5 g/L (20 ºC) | | Sensitive | Light Sensitive | | Merck | 14,7979 | | BRN | 234749 | | Stability: | Air Sensitive, Moisture Sensitive | | InChIKey | CEEQUQSGVRRXQI-UHFFFAOYSA-N | | CAS DataBase Reference | 41468-25-1(CAS DataBase Reference) |
| Pyridoxal 5'-phosphate monohydrate Usage And Synthesis |
| Chemical Properties | Pyridoxal Phosphate Hydrate occurs as a pale yellow-white to light yellow crystalline powder.It is slightly soluble in water, and practically insoluble in ethanol (99.5).It dissolves in dilute hydrochloric acid and in sodium hydroxide TS.The pH of a solution prepared by dissolving 0.1 g of Pyridoxal Phosphate Hydrate in 200 mL of water is between 3.0 and 3.5.Pyridoxal Phosphate Hydrate is colored to light red by light. | | Uses | Pyridoxal 5-phosphate (PLP) (active form of Vitamin B6) is an enzyme prosthetic group that acts as a coenzyme in transamination, decarboxylation and deamination reactions such as the conversion of dopa into dopamine; of glutamate into GABA; of histidine to histamine. PLP works mechanistically through formation of a Schiff-base. | | Application | Pyridoxal 5′-phosphate (PLP), an active form of vitamin B6/ pyridoxine is the coenzyme of amino acid metabolism.Pyridoxal 5′-phosphate monohydrate has been used:as a component in the reaction mixture for ornithine decarboxylase (ODC) activity assayas a standard to quantify the concentration of pyridoxal 5′-phosphate (PLP) in cerebrospinal fluid (CSF) of childrenas a dietary supplement to study its effects on the lethal phenotype of mutant flies. | | General Description | Pyridoxal 5'-phosphate (PLP, vitamin B6) is an essential cofactor in all living systems. It is one of the most versatile cofactors and participates in transamination, decarboxylation, racemization, Cα-Cβ cleavage and α-β elimination reactions. PLP plays an important role in amino acid and carbohydrate metabolism and has been implicated in singlet oxygen resistance. PLP can be used as a dietary supplement in cases of vitamin B6 deficiency. Reduced levels of PLP in the brain can cause neurological dysfunction. By inhibiting AGE formation and working as a coenzyme in chemical reactions, pyridoxal 5’-phosphate can support healthy nerve, eye, cardiovascular and kidney function. | | Biological Activity | Pyridoxine participates in the production of lipid and neurotransmitters. Pyridoxal 5′-phosphate (PLP) serves as a cofactor to stabilize carbanions at Cα of amino acids. Pyridoxine deficiency results in peripheral neuropathy. Absence of PLP leads to neonatal epileptic encephalopathy. PLP acts as a coenzyme in transamination, decarboxylation and deamination reactions such as the conversion of dopa into dopamine; of glutamate into γ aminobutyric acid (GABA); of histidine to histamine. PLP works mechanistically through formation of a Schiff-base. |
| Pyridoxal 5'-phosphate monohydrate Preparation Products And Raw materials |
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