Product

5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde

CAS No.：231278-84-5

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5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde Basic information

Product Name:	5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde
Synonyms:	5-(4-((3-Chloro-4-((3-fluorobenzyl);[5-[4-[4-[(3-Fluorobenzyl)oxy]-3-chloroanilino]-6-quinazolinyl]-2-furancarboxaldehyde;5-[4-[[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-6-quinazolinyl]-2-furancarboxaldehyde;5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde;Lapatinib intermediate 5-[4-[[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-6-quinazolinyl]-2-furancarboxaldehyde;5-[4-({3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}amino)quinazolin-6-yl]furan-2-carbaldehyde;5-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]-6-quinazolinyl]-2-furancarboxaldehyde;5-4-(3-CHLORO-4(3-LUOROBENZYLE)OXY)PHENYL)AMINO)QUINAZOLIN-6YL)-2-FURALDENHYDE
CAS:	231278-84-5
MF:	C26H17ClFN3O3
MW:	473.88
EINECS:	1806241-263-5
Product Categories:	Lapatinib;Various Intermediates;Intermediates;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:	231278-84-5.mol

5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde Chemical Properties

Melting point	227.0 to 231.0 °C
Boiling point	650.3±55.0 °C(Predicted)
density	1.407±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	DMSO (Slightly), Methanol (Very Slightly)
form	Solid
pka	5.18±0.30(Predicted)
color	Yellow to Dark Brown
CAS DataBase Reference	231278-84-5(CAS DataBase Reference)

Safety Information

MSDS Information

5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde Usage And Synthesis

Chemical Properties	Dark Brown Solid
Uses	Lapatinib intermediate.
Uses	Lapatinib intermediate

5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde Preparation Products And Raw materials

Raw materials

5-Formylfuran-2-boronic acid, pinacol ester-->N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine-->2-Formylfuran-5-boronic acid-->N-(3-Chloro-4-(3-fluorobenzyloxy)phenyl)-6-iodoquinazolin-4-aMine drochloride-->6-Bromo-N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]quinazolin-4-amine-->5-Formylfuran-2-boronic acid, neopentyl glycol ester

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