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| ailanthone Basic information |
| Product Name: | ailanthone | | Synonyms: | 11β,20-Epoxy-1β,11,12α-trihydroxypicrasa-3,13(21)-diene-2,16-dione;13,21-Didehydrochaparrinone;ailanthone;Picrasa-3,13(21)-diene-2,16-dione,11,20-epoxy-1,11,12-trihydroxy-, (1b,11b,12a)-;(1β,11β,12α)-11,20-Epoxy-1,11,12-trihydroxypicrasa-3,13(21)-diene-2,16-dione;Δ13-Dehydrochaparrinone;Picrasa-3,13(21)-diene-2,16-dione, 11,20-epoxy-1,11,12-trihydroxy-, (1β,11β,12α)-;(1beta,11alpha,12alpha)-1,11,12-trihydroxy-11,20-epoxypicras... | | CAS: | 981-15-7 | | MF: | C20H24O7 | | MW: | 376.4 | | EINECS: | | Product Categories: | Diterpenoids | | Mol File: | 981-15-7.mol |
| ailanthone Chemical Properties |
| Melting point | 235-237 °C | | Boiling point | 641.0±55.0 °C(Predicted) | | density | 1.47 | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | pka | 11.85±0.70(Predicted) |
| ailanthone Usage And Synthesis |
| Description | Ailanthone is a quassinoid that has been found in Ailanthus and has diverse biological activities. It is active against the P. falciparum strains HB-3 and Dd-2 in vitro (IC50s = 0.003 and 0.037 μg/ml, respectively). Ailanthone is phytotoxic, inhibiting radish seed germination by 88% when used at a concentration of 1 mM. It inhibits dihydrotestosterone-induced androgen receptor transcriptional activity (IC50 = 69 nM in a reporter assay), as well as the growth and colony formation of LNCaP and 22RV1 androgen receptor-expressing cells, but not androgen receptor-negative PC3 and DU145 cells, when used at a concentration of 0.1 μM. Ailanthone (2 mg/kg) reduces tumor volume in 22Rv1, LNCaP, and VCaP castration-resistant prostate cancer (CRPC) mouse xenograft models. | | Uses | Ailanthone has potent antineoplastic activity against anti-hepatocellular carcinoma (HCC) and has been shown to inhibit Huh7 cancer cell growth through cell cycle arrest and apoptosis in vitro and in vivo. |
| ailanthone Preparation Products And Raw materials |
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