4-Amidinophenylmethanesulfonyl fluoride hydrochloride

CAS No.：74938-88-8

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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4-Amidinophenylmethanesulfonyl fluoride hydrochloride Basic information

Product Name:	4-Amidinophenylmethanesulfonyl fluoride hydrochloride
Synonyms:	APMSF HCL;APMSF HYDROCHLORIDE;4-AMIDINOPHENYLMETHANESULFONYL FLUORIDE HYDROCHLORI;P-APMSF;P-APMSF, HYDROCHLORIDE;(P-AMIDINOPHENYL)METHANESULFONYL FLUORIDE HYDROCHLORIDE;P-AMIDINOPHENYLMETHYLSULFONYLFLUORIDE, HCL;P-AMIDINOPHENYLMETHYL-SULFONYLFLUORIDE HYDROCHLORIDE
CAS:	74938-88-8
MF:	C8H10ClFN2O2S
MW:	252.69
EINECS:
Product Categories:	inhibitor
Mol File:	74938-88-8.mol

4-Amidinophenylmethanesulfonyl fluoride hydrochloride Chemical Properties

Melting point	~205 °C (dec.)
storage temp.	-20°C
solubility	H₂O: 50 mM Stable when aliquoted at −20°C. Half-life = 6 minutes in pH 7.0 buffer systems.
form	White solid
BRN	9083148
InChIKey	KHLLRHIUKOJXLL-UHFFFAOYSA-N
CAS DataBase Reference	74938-88-8(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn
Risk Statements	20/21/22-36/37/38
Safety Statements	22-24/25-36-26
WGK Germany	3
F	10-21
HS Code	29252900

MSDS Information

Provider	Language
SigmaAldrich	English

4-Amidinophenylmethanesulfonyl fluoride hydrochloride Usage And Synthesis

Description	p-APMSF is an irreversible inhibitor of serine proteases with K_i values of 1.02, 1.18, 1.5, and 1.54 μM for bovine trypsin, human thrombin, bovine plasmin, and bovine Factor Xa, respectively. It is selective for these proteases over bovine chymotrypsin and acetylcholinesterase.
Biochem/physiol Actions	Irreversible inhibitor of serine proteases with lysine or arginine substrate specificities. Effective concentration 10-100 μM. Frequently used to characterize newly discovered proteases.

4-Amidinophenylmethanesulfonyl fluoride hydrochloride Preparation Products And Raw materials

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