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| 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE Basic information |
| Product Name: | 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE | | Synonyms: | 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE;JSH-23;4-Methyl-N1-(3-phenylpropyl)-1,2-benzenediamine;4-Methyl-N1-(3-phenylpropyl)-1,2-benzenediamine JSH 23;JSH-23;JSH23;JSH 23;NF-ΚB ACTIVATION INHIBITOR II;NF-κB Activation Inhibitor II;JSH 23 4-Methyl-N1-(3-phenylpropyl)-1,2-benzenediamine;4-Methyl-N1-(3-phenylpropyl)-1,2-phenylenediamine | | CAS: | 749886-87-1 | | MF: | C16H20N2 | | MW: | 240.34 | | EINECS: | | Product Categories: | Chemical Amines;Amines;Aromatics;Inhibitors | | Mol File: | Mol File |
| 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE Chemical Properties |
| Melting point | 104.4-105.0℃ | | Boiling point | 418.7±40.0 °C(Predicted) | | density | 1.086±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO: >10mg/mL | | pka | 5.99±0.11(Predicted) | | form | solid | | color | off-white to gray-pink |
| 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE Usage And Synthesis |
| Uses | A cell-permeable, selective blocker of nuclear translocation of NF-KB p65. NF-KB activation inhibitor II, JSH-23 | | Uses | JSH-23 is a cell-permeable, selective blocker of nuclear translocation of NF-KB p65. NF-KB activation inhibitor II. | | Uses | JSH-23 has been used as a nuclear factor κB (NF-κB) p65 inhibitor. | | General Description | A cell-permeable diamino compound that selectively blocks nuclear translocation of NF-κB p65 and its transcription activity (IC50 = 7.1 μM in a NF-κB reporter assay using RAW 264.7) without affecting IκB degradation. Shown to suppress DNA-binding of NF-κB and downregulate LPS-induced gene expression and apoptotic chromatin condensation. | | Biological Activity | jsh-23 is an inhibitor of nf-κb transcriptional activity with ic50 value of 7.1μm [1].jsh-23 is developed to inhibit nf-κb transcriptional activity in lps-stimulated macrophages raw 264.7. it shows a dose-dependent inhibition. this effect is not due to its cytotoxicity. in the same condition, jsh-23 is found to significantly decrease the lps-induced dna binding activity of nf-κb while decrease nuclear amount of nf-κb p65. jsh-23 plays these roles without affecting iκb degradation. in addition, jsh-23 also shows inhibition effects on the expression of the pro-inflammatory transcripts and enzymes, including il-6, il-1β, cox-2 and tnf-α. furthermore, jsh-23 inhibits lps-induced apoptotic chromatin condensation [1]. | | Biochem/physiol Actions | Primary TargetBlocks nuclear translocation of NF-κB p65 and its transcription activity | | references | [1] shin hm, kim mh, kim bh, jung sh, kim ys, park hj, hong jt, min kr, kim y. inhibitory action of novel aromatic diamine compound on lipopolysaccharide-induced nuclear translocation of nf-kappab without affecting ikappab degradation. febs lett. 2004 jul 30;571(1-3):50-4. |
| 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE Preparation Products And Raw materials |
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