Other grades of this product :
| Flavopiridol Basic information |
| Product Name: | Flavopiridol | | Synonyms: | FLAVOPIRIDOL;2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3s,4r)-3-hydroxy-1-methyl-4-piperidyl]chromen-4-one;4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-;Alvocidib;(-)cis-5,7-Dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one;C077990;Hmr 1275;L 868275 | | CAS: | 146426-40-6 | | MF: | C21H20ClNO5 | | MW: | 401.84 | | EINECS: | | Product Categories: | API intermediates | | Mol File: | 146426-40-6.mol |
| Flavopiridol Chemical Properties |
| Melting point | 52.5 °C | | Boiling point | 603.6±55.0 °C(Predicted) | | density | 1.448±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | insoluble in H2O; ≥40.2 mg/mL in DMSO; ≥85.4 mg/mL in EtOH with gentle warming and ultrasonic | | form | Yellow powder. | | pka | 6.16±0.40(Predicted) | | CAS DataBase Reference | 146426-40-6(CAS DataBase Reference) |
| Flavopiridol Usage And Synthesis |
| Uses | Antineoplastic (cyclin-dependent kinase
inhibitor)[Note—The trivial name, flavopiridol, has
appeared in literature]. | | Uses | Flavopiridol is a synthetic flavonoid derivative, potent inhibitor of CDKs. Inhibitor of CDK9 as a postexposure drug target for adenoviruses. | | Anticancer Research | It is a synthetic derivative of rohitukine plant alkaloid which is obtained fromDysoxylum binectariferum, which is active against leukemia, lymphomas and solidtumors (Shoeb 2006). |
| Flavopiridol Preparation Products And Raw materials |
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