| N-(Trimethylsilyl)acetamide Basic information |
| Product Name: | N-(Trimethylsilyl)acetamide |
| Synonyms: | N-(TRIMETHYLSILYL)ACETAMIDE FOR SYNTHESI;N-(Trimethylsilyl)acetamide,97%;N-(Trimethylsilyl);(acetylamino)trimethylsilane;n-(trimethylsilyl)-acetamid;N-TRIMETHYLSILYLACETAMIDE;TRIMETHYLSILYLACETAMIDE;TMSA |
| CAS: | 13435-12-6 |
| MF: | C5H13NOSi |
| MW: | 131.25 |
| EINECS: | 236-565-7 |
| Product Categories: | Aliphatics;Miscellaneous Reagents;Analytical Chemistry;GC Derivatizing Reagents;Si (Classes of Silicon Compounds);Silicon Compounds (for Synthesis);Silylacetamides;Silylation (GC Derivatizing Reagents);Si-N Compounds;Synthetic Organic Chemistry;Trimethylsilylation (GC Derivatizing Reagents) |
| Mol File: | 13435-12-6.mol |
| N-(Trimethylsilyl)acetamide Chemical Properties |
| Melting point | 46-49 °C(lit.) |
| Boiling point | 84 °C18 mm Hg(lit.) |
| density | 0.859±0.06 g/cm3(Predicted) |
| Fp | 135 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform, DMSO, Methanol |
| form | Crystalline Mass |
| pka | 18.23±0.46(Predicted) |
| color | White to yellow |
| Water Solubility | reacts |
| Hydrolytic Sensitivity | 7: reacts slowly with moisture/water |
| Sensitive | Moisture Sensitive |
| BRN | 741928 |
| Stability: | Moisture Sensitive |
| CAS DataBase Reference | 13435-12-6(CAS DataBase Reference) |
| EPA Substance Registry System | Acetamide, N-(trimethylsilyl)- (13435-12-6) |
| Safety Information |
| Hazard Codes | Xi-F,Xi,F |
| Risk Statements | 36/37/38-11 |
| Safety Statements | 37/39-26 |
| RIDADR | 1325 |
| WGK Germany | 3 |
| RTECS | AD0250000 |
| F | 10-21 |
| TSCA | Yes |
| HazardClass | 4.1 |
| PackingGroup | III |
| HS Code | 29319090 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| ACROS | English |
| ALFA | English |
| N-(Trimethylsilyl)acetamide Usage And Synthesis |
| Chemical Properties | WHITE TO YELLOWISH CRYSTALLINE MASS |
| Uses | N-Trimethylsilylacetamide is a silylating agent used in organic synthesis. N-Trimethylsilylacetamide is used in the preparation of the antibacterial agent Cefdinir (C242670). |
| General Description | The efficiency of N-(Trimethylsilyl)acetamide (TMS acetamide) as allyl group scavenger and its compatibility with Fluorenylmethyloxycarbonyl chloride (Fmoc) protecting groups were studied. |
| Purification Methods | Distil the amide repeatedly in an inert atmosphere with all operations to be performed in an anhydrous atmosphere. In the presence of moisture, trimethylsilanol (b 31-34o/26mm) is formed and is a likely impurity (check by NMR). [Birkofer et al. Chem Ber 96 1473 1963, Beilstein 4 IV 4011.] |
| N-(Trimethylsilyl)acetamide Preparation Products And Raw materials |
| Preparation Products | Cefdinir-->2-METHYL-1-(TRIMETHYLSILOXY)-1-PROPENE-->1-(Trimethylsiloxy)cyclopentene |
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