Other grades of this product :
| GLYCOFUROL Basic information |
| GLYCOFUROL Chemical Properties |
| Boiling point | 100-145 °C0.4 mm Hg | | density | 1.09 g/mL at 25 °C(lit.) | | vapor pressure | 4.97-37.4Pa at 20-50℃ | | refractive index | n20/D 1.462(lit.) | | Fp | >230 °F | | storage temp. | Store below +30°C. | | Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. | | LogP | -1.21--0.38 |
| WGK Germany | 3 | | RTECS | MD0907500 | | HS Code | 3907 20 20 |
| GLYCOFUROL Usage And Synthesis |
| Chemical Properties | liquid | | Chemical Properties | Glycofurol is a clear, colorless, almost odorless liquid, with a bitter
taste; it produces a warm sensation on the tongue. | | Uses | Glycofurol is used as a carrier device for drug delivery. | | Uses | Used as solvent to dissolve water-insoluble compounds. | | Production Methods | Glycofurol is prepared by the reaction of tetrahydrofurfuryl alcohol
with ethylene oxide (followed by a special purification process in
the case of Glycofurol 75). | | Pharmaceutical Applications | Glycofurol is used as a solvent in parenteral products for
intravenous or intramuscular injection in concentrations up to
50% v/v. It has also been investigated, mainly in animal studies,
for use as a penetration enhancer and solvent in topical and
intranasal formulations. Glycofurol has also been used at 20%
v/v concentration in a rectal formulation. | | Safety | Glycofurol is mainly used as a solvent in parenteral pharmaceutical
formulations and is generally regarded as a relatively nontoxic and
nonirritant material at the levels used as a pharmaceutical excipient.
Glycofurol can be irritant when used undiluted; its tolerability is
approximately the same as propylene glycol.
Glycofurol may have an effect on liver function and may have a
low potential for interaction with hepatoxins or those materials
undergong extensive hepatic metabolism.
LD50 (mouse, IV): 3.5 mL/kg | | storage | Stable if stored under nitrogen in a well-closed container protected
from light, in a cool, dry place. | | Incompatibilities | Incompatible with oxidizing agents. | | Regulatory Status | Included in parenteral medicines licensed in Europe. |
| GLYCOFUROL Preparation Products And Raw materials |
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