4-AMINO-3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDINE

CAS No.：151266-23-8

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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4-AMINO-3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDINE Basic information

Product Name:	4-AMINO-3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDINE
Synonyms:	3-iodo-2H-pyrazolo[3,4-d]pyrimidin-4-amine;3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE;4-AMINO-3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDINE;4-Amino-3-iodopyrazolo[3,4-d]pyrimidine;1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-iodo-;4-Amino-3-iodo-1H-pyrazolo[3,4-D]pyridine;3-iodo-4-AMino-1H-pyrazolo[3,4-d]pyridine;7-Iodo-7-deaza-8-aza-adenine
CAS:	151266-23-8
MF:	C5H4IN5
MW:	261.02
EINECS:
Product Categories:	Heterocycle-Pyridine series;pharmacetical
Mol File:	151266-23-8.mol

4-AMINO-3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDINE Chemical Properties

Boiling point	312.3±52.0 °C(Predicted)
density	2.92±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	powder to crystal
pka	10.50±0.20(Predicted)
color	White to Light yellow to Light orange
Sensitive	Light Sensitive
λmax	282nm(lit.)

Safety Information

Hazard Codes	Xn
Risk Statements	36/37/38-22
Safety Statements	26-36/37/39-37
TSCA	N
HS Code	29335990

MSDS Information

4-AMINO-3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDINE Usage And Synthesis

Uses

3-Iodo-3H-pyrazolo[3,4-d]pyrimidin-4-amine acts as a reagent in the discovery and preparation of CHMFL-FLT3-122 as potent and orally available FLT3 kinase inhibitor for FLT3-ITD positive acute myeloid leukemia. Development and preparation of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes.

4-AMINO-3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDINE Preparation Products And Raw materials

Raw materials	4-Chloro-1H-pyrazolo[3,4-d]pyrimidine-->4-Aminopyrazolo[3,4-d]pyrimidine-->2H-Pyrazolo[3,4-d]pyrimidin-4-amine (9CI)-->N-Iodosuccinimide
Preparation Products	(3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine

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