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| DIISOPROPYLDICHLOROSILANE Basic information |
| DIISOPROPYLDICHLOROSILANE Chemical Properties |
| Melting point | <0°C | | Boiling point | 66 °C27 mm Hg(lit.) | | density | 1.026 g/mL at 20 °C(lit.) | | refractive index | n20/D 1.444 | | Fp | 43°C | | solubility | sol most organic solvents. | | form | clear liquid | | color | Colorless to Light yellow to Light orange | | Specific Gravity | 1.026 | | Hydrolytic Sensitivity | 8: reacts rapidly with moisture, water, protic solvents | | BRN | 1736244 | | CAS DataBase Reference | 7751-38-4(CAS DataBase Reference) |
| Hazard Codes | C | | Risk Statements | 10-34 | | Safety Statements | 28-36/37/39-45 | | RIDADR | UN 2986 8/PG 2 | | WGK Germany | 3 | | F | 10-21 | | TSCA | No | | HazardClass | 3/8 | | PackingGroup | II | | HS Code | 29319090 |
| DIISOPROPYLDICHLOROSILANE Usage And Synthesis |
| Physical properties | bp 50–55°C/5 mmHg. | | Uses | Dichlorodiisopropylsilane can be used in nucleoside 3',5'-hydroxy protection; component in Peterson
alkenation reaction.The use of silicon groups as
protection for hydroxy groups has been widely exploited.3 One
potentially useful way to protect a nucleoside is by using a protecting
group which spans the 3- and 5-hydroxy groups. One of
the useful groups which can be used as a bifunctional protecting
group in nucleosides is the diisopropylsilyl group. Reaction of the
nucleoside with dichlorodiisopropylsilane and imidazole in DMF
gives the protected nucleoside (eq 1).This method has not been widely used; the more common 3',5'-hydroxy-bridging protecting
group is a tetraisopropyldisiloxy group. | | Preparation | conveniently prepared by the reaction of diisopropylsilane
in carbon tetrachloride with palladium(II) chloride
at 140°C for 8 h in a steel bomb.Washing the residue with
ether and removing the ether by rotary evaporation yields the
product which is purified by distillation to yield a clear colorless
oil. |
| DIISOPROPYLDICHLOROSILANE Preparation Products And Raw materials |
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