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| Propargyl-PEG4-acid Basic information |
| Product Name: | Propargyl-PEG4-acid | | Synonyms: | Propargyl-PEG4-acid;Propargyl-PEG4-CH2CO2H;Propyne-PEG3-CH2CH2COOH;Alkyne-PEG4-COOH;PROPARGYL-PEG4-COOH;Propargyl-PEG3-CH2CH2COOH;4,7,10,13-tetraoxahexadec-15-ynoic acid;4,7,10,13-Tetraoxahexadec-15-yn-1-oic acid | | CAS: | 1415800-32-6 | | MF: | C12H20O6 | | MW: | 260.28 | | EINECS: | | Product Categories: | peg | | Mol File: | 1415800-32-6.mol |
| Propargyl-PEG4-acid Chemical Properties |
| Boiling point | 388.0±37.0 °C(Predicted) | | density | 1.129±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in Water, DMSO, DCM, DMF | | pka | 4.28±0.10(Predicted) |
| Propargyl-PEG4-acid Usage And Synthesis |
| Description | Propargyl-PEG4-acid is a PEG reagent with an alkyne and a terminal carboxylic acid. The carboxylic acid reacts with primary amine groups with the help of activators (e.g. EDC, or HATU). The 4-unit PEG spacer increases hydrophilicity. The alkyne can participate in copper-catalyzed Click Chemistry. | | Uses | This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation. |
| Propargyl-PEG4-acid Preparation Products And Raw materials |
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